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Growing evidence is linking coffee consumption with reduced risk of disease progression in various CLDs, including metabolic dysfunction associated steatotic liver disease (MASLD), alcoholic liver disease, hepatitis B and C, autoimmune hepatitis, and a reduction in the risk of hepatocellular carcinoma development. Coffee, a globally consumed beverage, contains bioactive compounds like caffeine, chlorogenic acids, diterpenes, and polyphenols, which may offer hepatoprotective benefits through anti\u2010inflammatory, antioxidant, and metabolic regulatory effects. This narrative review discusses the current evidence demonstrating an inverse correlation between regular coffee intake and CLD progression, highlighting dose\u2010dependent benefits with optimal consumption at three to four cups per day. Potential mechanisms for hepatoprotective effects of coffee involve modulation of the gut\u2010liver axis, epigenetic regulation, and improving liver transaminitis. Additionally, the current review explores the effects of different coffee processing methods, such as roasting levels and brewing techniques, on these protective properties. Coffee's role as an affordable, culturally accepted intervention to mitigate the burden of CLD offers a compelling avenue for future public health strategies. Despite promising evidence, there is a need for further proof to establish the most beneficial coffee preparation methods.<\/jats:p>","DOI":"10.1111\/jvh.70072","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T12:41:29Z","timestamp":1757335289000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Protective Role of Coffee in Chronic Liver Disease: A Focus on Processing"],"prefix":"10.1111","volume":"32","author":[{"given":"Rofida","family":"Khalifa","sequence":"first","affiliation":[{"name":"Tropical Medicine Department, Faculty of Medicine Minia University  El Menia Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2892-266X","authenticated-orcid":false,"given":"Khalid","family":"Al\u2010Naamani","sequence":"additional","affiliation":[{"name":"Department of Medicine, Division of Gastroenterology and Hepatology The Medical City for Military and Security Services  Muscat Oman"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Elbadry","sequence":"additional","affiliation":[{"name":"Endemic Medicine Department Faculty of Medicine, Helwan University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Yuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Drug\u2010Targeting and Drug Delivery System of the Education Ministry and Sichuan Province, and Sichuan Research Center for Drug Precision Industrial Technology, West China School of Pharmacy Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3521-8523","authenticated-orcid":false,"given":"Khalid","family":"Alswat","sequence":"additional","affiliation":[{"name":"Liver Disease Research Center, College of Medicine King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3396-6894","authenticated-orcid":false,"given":"Mohamed","family":"El\u2010Kassas","sequence":"additional","affiliation":[{"name":"Endemic Medicine Department Faculty of Medicine, Helwan University  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.017"},{"issue":"6","key":"e_1_2_11_3_1","first-page":"903","article-title":"Coffee Reduces Risk for Hepatocellular Carcinoma: An Updated Meta\u2010Analysis","volume":"15","author":"Bravi F.","year":"2013","journal-title":"Clinical Gastroenterology and Hepatology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24731"},{"key":"e_1_2_11_5_1","unstructured":"M.Ridder \u201cCoffee Consumption Worldwide From 2012\/13 to 2023\/24 With a Forecast to 2022\/23. 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