{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:15:04Z","timestamp":1791332104935,"version":"4.3.1"},"reference-count":64,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T00:00:00Z","timestamp":1757376000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008982","name":"Qatar National Research Fund","doi-asserted-by":"publisher","award":["NPRP 12S\u20100216\u2010190094"],"award-info":[{"award-number":["NPRP 12S\u20100216\u2010190094"]}],"id":[{"id":"10.13039\/100008982","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019460","name":"Weill Cornell Medicine - Qatar","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019460","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hepatitis B virus (HBV) infection is a global health challenge, with the World Health Organization (WHO) targeting its elimination by 2030. Jordan lacks sufficient data on HBV epidemiology, including prevalence, incidence and clearance. This study addresses these gaps through a retrospective analysis of HBV testing data from 40,268 individuals collected at Biolab Diagnostic Laboratories (2010\u20132024). Using cross\u2010sectional and cohort study designs, the study examined hepatitis B surface antigen (HBsAg) prevalence, temporal trends, incidence, clearance rates and associated risk factors. Statistical methods included regression analyses, Kaplan\u2013Meier estimations and Poisson models. HBsAg prevalence was 3.8% (95% CI: 3.6%\u20134.0%), with a nationally weighted prevalence of 5.3% (95% CI: 4.4%\u20136.4%). Prevalence was around 1% in individuals under 20\u2009years, increasing to 8.5% (95% CI: 7.7%\u201310.0%) in the 50\u201359 age group. Over the past 15\u2009years, prevalence declined by 7% annually [adjusted odds ratio (aOR): 0.93; 95% CI: 0.92\u20130.94]. HBsAg positivity was significantly associated with age, male sex and governorate. Cumulative HBsAg incidence was 0.26% (95% CI: 0.11%\u20130.64%) after 5\u2009years of follow\u2010up, with an incidence rate of 0.63 per 1000 person\u2010years (95% CI: 0.26\u20131.51). Cumulative HBsAg clearance was 7.45% (95% CI: 4.07%\u201313.43%) at the 6\u2010month follow\u2010up mark, with a clearance rate of 17.68 per 100 person\u2010years (95% CI: 9.51\u201332.86). Among HBsAg\u2010positive individuals with &gt;\u20096\u2009months of follow\u2010up, cumulative HBsAg clearance reached 46.12% (95% CI: 24.50%\u201374.34%) after 13\u2009years of follow\u2010up, with a clearance rate of 5.27 per 100 person\u2010years (95% CI: 3.32\u20138.36). HBV epidemiology in Jordan shows declining prevalence and incidence, likely driven by expanding HBV vaccination coverage. To meet the WHO's 2030 elimination targets, Jordan must prioritise scaling up birth\u2010dose vaccination, improving case detection and ensuring timely treatment.<\/jats:p>","DOI":"10.1111\/jvh.70075","type":"journal-article","created":{"date-parts":[[2025,9,9]],"date-time":"2025-09-09T12:36:17Z","timestamp":1757421377000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Hepatitis B Virus in Jordan: Prevalence, Incidence and Clearance From Cross\u2010Sectional and Cohort Studies"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0224-2292","authenticated-orcid":false,"given":"Issa","family":"Abu\u2010Dayyeh","sequence":"first","affiliation":[{"name":"Department of Research and Development Biolab Diagnostic Laboratories  Amman Jordan"},{"name":"Department of Diagnostic Immunology Biolab Diagnostic Laboratories  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8756-6968","authenticated-orcid":false,"given":"Hiam","family":"Chemaitelly","sequence":"additional","affiliation":[{"name":"Infectious Disease Epidemiology Group, Weill Cornell Medicine\u2010Qatar Cornell University  Doha Qatar"},{"name":"Department of Population Health Sciences, Weill Cornell Medicine Cornell University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9044-0058","authenticated-orcid":false,"given":"Ahmad","family":"Al Tibi","sequence":"additional","affiliation":[{"name":"Department of Research and Development Biolab Diagnostic Laboratories  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Ghunaim","sequence":"additional","affiliation":[{"name":"Department of Research and Development Biolab Diagnostic Laboratories  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thaer","family":"Hasan","sequence":"additional","affiliation":[{"name":"Department of Research and Development Biolab Diagnostic Laboratories  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amid","family":"Abdelnour","sequence":"additional","affiliation":[{"name":"Department of Research and Development Biolab Diagnostic Laboratories  Amman Jordan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0790-0506","authenticated-orcid":false,"given":"Laith J.","family":"Abu\u2010Raddad","sequence":"additional","affiliation":[{"name":"Infectious Disease Epidemiology Group, Weill Cornell Medicine\u2010Qatar Cornell University  Doha Qatar"},{"name":"Department of Population Health Sciences, Weill Cornell Medicine Cornell University  New York New York USA"},{"name":"Department of Public Health, College of Health Sciences, QU Health Qatar University  Doha Qatar"},{"name":"College of Health and Life Sciences Hamad Bin Khalifa University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,9]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Health Organization \u201cGlobal Hepatitis Report 2024 \u201d(2024) https:\/\/www.who.int\/publications\/i\/item\/9789240091672."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30579-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-023-00760-9"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00197-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(18)30056-6"},{"key":"e_1_2_11_7_1","unstructured":"World Health Organization \u201cGlobal Health Sector Strategies on Respectively HIV Viral Hepatitis and Sexually Transmitted Infections for the Period 2022\u20132030 \u201d(2022) file:\/\/\/C:\/Users\/gm15\/Downloads\/9789240053779\u2010eng.pdf."},{"key":"e_1_2_11_8_1","unstructured":"United Nations \u201cWorld Population Prospects \u201d(2024) https:\/\/population.un.org\/wpp\/downloads."},{"key":"e_1_2_11_9_1","unstructured":"W.Hamoudi M.Al Zyoud andN.Abu Farsakh \u201cThe Hashemite Kingdom of Jordan\u2014Ministry of Health. 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