{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:08:55Z","timestamp":1784581735325,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T00:00:00Z","timestamp":1757980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hepatitis B virus\u2010related acute\u2010on\u2010chronic liver failure (HBV\u2010ACLF) is a life\u2010threatening condition with high short\u2010term mortality, making early prognosis crucial. The liver\u2010to\u2010spleen volume ratio (LSVR) provides important prognostic information but is not included in current tools. This study evaluated the link between LSVR from computed tomography and short\u2010term mortality in HBV\u2010ACLF patients. The study included 278 patients, divided into five groups based on LSVR quintiles. The main outcome was 28\u2010day mortality, with a secondary focus on 90\u2010day mortality. Multivariable Cox regression and restricted cubic splines were used to analyse the LSVR\u2010mortality relationship. Participants had a mean age of 48\u2009years, 82.7% were male, with 28\u2010 and 90\u2010day mortality rates of 23.4% and 31.3%, respectively. After adjusting for covariates, the risk of 28\u2010day mortality was elevated by 553% (OR 6.53, 95% CI 1.86\u201323) in the highest quintile of LSVR (Q5\u2009\u2265\u20093.6) and by 343% (OR 4.43, 95% CI 1.14\u201317.16) in the lowest quintile (Q1\u2009\u2264\u20091.6), as compared to the reference quintile (Q3 2.4\u20132.9). The curve\u2010fitting results showed a U\u2010shaped relationship between LSVR and the risk of 28\u2010day mortality and 90\u2010day mortality, with an infection point of 2.7. There is a U\u2010shaped relationship between LSVR and mortality in HBV\u2010ACLF patients. Higher or lower LSVR is associated with an increased risk of short\u2010term mortality in HBV\u2010ACLF patients.<\/jats:p>","DOI":"10.1111\/jvh.70076","type":"journal-article","created":{"date-parts":[[2025,9,16]],"date-time":"2025-09-16T11:46:41Z","timestamp":1758023201000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["U\u2010Shaped Relationship Between CT\u2010Measured Liver\u2010To\u2010Spleen Volume Ratio and Mortality in HBV\u2010ACLF Patients"],"prefix":"10.1111","volume":"32","author":[{"given":"Libo","family":"Yan","sequence":"first","affiliation":[{"name":"Center of Infectious Diseases West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8882-173X","authenticated-orcid":false,"given":"Man","family":"Yuan","sequence":"additional","affiliation":[{"name":"Center of Infectious Diseases West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mao","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Radiology, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-0979-7478","authenticated-orcid":false,"given":"Kunping","family":"Cui","sequence":"additional","affiliation":[{"name":"Center of Infectious Diseases West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2581-1048","authenticated-orcid":false,"given":"Xiangnan","family":"Teng","sequence":"additional","affiliation":[{"name":"Center of Infectious Diseases West China Hospital of Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department 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