{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:16:25Z","timestamp":1758845785279,"version":"3.44.0"},"reference-count":10,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Hepatitis E virus infection typically results in a self\u2010limited acute viral hepatitis (AVH\u2010E), which is rapidly cleared by the host immune response. In this longitudinal study, temporal cytokine and chemokine profiles were analysed in AVH\u2010E patients' sera using a multiplex immunoassay. HEV RNA became undetectable between 9 and 18\u2009days, with a median of 13\u2009days, occurring 3\u201320\u2009days after symptom onset. In the AVH\u2010E group, IFN\u2010\u03b3 peaked significantly around days 6\u20139, which is prior to the HEV RNA clearance period, and declined during days 9\u201318. IL\u20102, IL\u201010, and TNF\u2010\u03b1 increased significantly during days 15\u201320, while IL\u20101\u03b2 and IL\u20106 showed peak levels. CCL3, CXCL6, CXCL9, CXCL10 and MIF were significantly higher in the AVH\u2010E group than in the healthy controls; CCL2 and CCL20 peaked non\u2010significantly during days 12\u201317. CCL3, CXCL6, CXCL9 and CXCL10 levels were lower in the AVH\u2010E group than in the AVH\u2010B group. Compared to the AVH\u2010B group and healthy controls, the AVH\u2010E group showed distinct immune signatures. These findings highlight coordinated cytokine and chemokine responses during HEV infection and provide insights into the immunopathogenesis of self\u2010limiting hepatitis E.<\/jats:p>","DOI":"10.1111\/jvh.70088","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T13:05:37Z","timestamp":1758114337000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Longitudinal Profiles of Cytokines and Chemokines in Self\u2010Limiting Hepatitis E"],"prefix":"10.1111","volume":"32","author":[{"given":"Pooja","family":"Bhatia","sequence":"first","affiliation":[{"name":"Virology Section, Department of Life Sciences Shiv Nadar Institution of Eminence  Gautam Buddha Nagar Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-1433-5730","authenticated-orcid":false,"given":"Aas","family":"Mohd","sequence":"additional","affiliation":[{"name":"Virology Section, Department of Life Sciences Shiv Nadar Institution of Eminence  Gautam Buddha Nagar Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshita","family":"Katiyar","sequence":"additional","affiliation":[{"name":"Department of Hepatology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3525-9381","authenticated-orcid":false,"given":"Amit","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Hepatology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rakesh","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Sanjay Gandhi Postgraduate Institute of Medical Sciences  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8438-1466","authenticated-orcid":false,"given":"Naga Suresh","family":"Veerapu","sequence":"additional","affiliation":[{"name":"Virology Section, Department of Life Sciences Shiv Nadar Institution of Eminence  Gautam Buddha Nagar Uttar Pradesh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1005521"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a032136"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13266"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2010.06356.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2019.08.006"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0031822"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-011-1291-1"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13885"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11060541"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2006.0053"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.70088","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,9,25]],"date-time":"2025-09-25T11:14:57Z","timestamp":1758798897000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.70088"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9,17]]},"references-count":10,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,10]]}},"alternative-id":["10.1111\/jvh.70088"],"URL":"https:\/\/doi.org\/10.1111\/jvh.70088","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"type":"print","value":"1352-0504"},{"type":"electronic","value":"1365-2893"}],"subject":[],"published":{"date-parts":[[2025,9,17]]},"assertion":[{"value":"2025-04-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-10","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70088"}}