{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T01:58:16Z","timestamp":1792979896144,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003323","name":"Agence Nationale de Recherches sur le Sida et les H\u00e9patites Virales","doi-asserted-by":"publisher","award":["ANRS 12380"],"award-info":[{"award-number":["ANRS 12380"]}],"id":[{"id":"10.13039\/501100003323","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>People who inject drugs (PWID) are highly affected by hepatitis C (HCV) worldwide, particularly in low\u2010 and middle\u2010income countries (LMICs), where access to addiction services is often limited. Reducing the burden of HCV, as promoted by WHO, requires effective interventions in this high\u2010risk population. Here, we report the safety and efficacy of a pangenotypic generic HCV treatment among PWID in Vietnam, using a sofosbuvir\/daclatasvir regimen. PWID were screened for HCV at two community\u2010based organisations (CBO) premises in Haiphong during both a respondent\u2010driven sampling survey and cohort follow\u2010up visits. PWID with detectable HCV RNA were referred to three public hospitals for a 12\u2010week regimen of generic sofosbuvir\/daclatasvir, with ribavirin if cirrhosis, and with CBO support for referral and adherence. Treatment safety was assessed over the course of treatment and success was measured by sustained virologic response 12\u2009weeks after the end of treatment (SVR12). Of the 1201 PWID screened with detectable HCV RNA, 1021 were enrolled: 96% male, median age 42\u2009years, 45% HIV\u2010infected, 16% with advanced liver fibrosis, 55% currently injecting, and 71.5% on methadone maintenance therapy (MMT). In total, 979 participants started HCV treatment, and 901 of the 924 participants tested at SVR12 (98%) were cured. Genotype 3, current drug use, lack of MMT, and HIV infection were independently associated with treatment failure. High HCV cure rates can be achieved among PWID in LMICs such as Vietnam using a simple model of care, including a pangenotypic generic direct\u2010acting antiviral combination and CBO support.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT03537196\n                  <\/jats:p>","DOI":"10.1111\/jvh.70090","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T10:31:36Z","timestamp":1759141896000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["High Efficiency and Safety of Hepatitis C Treatment Among People Who Inject Drugs in Vietnam"],"prefix":"10.1111","volume":"32","author":[{"given":"Didier","family":"Laureillard","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Department University Hospital  N\u00eemes France"},{"name":"Pathogenesis and Control of Chronic and Emerging Infections Universit\u00e9 de Montpellier, Inserm, Universit\u00e9 des Antilles,  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nguyen Thanh","family":"Binh","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Department Viet Tiep Hospital  Hai Phong Vietnam"},{"name":"Faculty of Public Health Hai Phong University of Medicine and Pharmacy  Hai Phong Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vu Hai","family":"Vinh","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Department Viet Tiep Hospital  Hai Phong Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tran Thi","family":"Hong","sequence":"additional","affiliation":[{"name":"Faculty of Public Health Hai Phong University of Medicine and Pharmacy  Hai Phong Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Quillet","sequence":"additional","affiliation":[{"name":"Pathogenesis and Control of Chronic and Emerging Infections Universit\u00e9 de Montpellier, Inserm, Universit\u00e9 des Antilles,  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nham Thi Tuyet","family":"Thanh","sequence":"additional","affiliation":[{"name":"Center for Supporting Community Development Initiatives  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roselyne","family":"Vallo","sequence":"additional","affiliation":[{"name":"Pathogenesis and Control of Chronic and Emerging Infections Universit\u00e9 de Montpellier, Inserm, Universit\u00e9 des Antilles,  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bach Thi Nhu","family":"Quynh","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology Hai Phong University of Medicine and Pharmacy  Hai Phong Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6863-6350","authenticated-orcid":false,"given":"Jean Pierre","family":"Moles","sequence":"additional","affiliation":[{"name":"Pathogenesis and Control of Chronic and Emerging Infections Universit\u00e9 de Montpellier, Inserm, Universit\u00e9 des Antilles,  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khuat Thi Hai","family":"Oanh","sequence":"additional","affiliation":[{"name":"Center for Supporting Community Development Initiatives  Hanoi Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duong Thi","family":"Huong","sequence":"additional","affiliation":[{"name":"Faculty of Public Health Hai Phong University of Medicine and Pharmacy  Hai Phong Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Rapoud","sequence":"additional","affiliation":[{"name":"Pathogenesis and Control of Chronic and Emerging Infections Universit\u00e9 de Montpellier, Inserm, Universit\u00e9 des Antilles,  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Feelemyer","sequence":"additional","affiliation":[{"name":"School of Global Public Health New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurent","family":"Michel","sequence":"additional","affiliation":[{"name":"CESP Inserm UMRS 1018, Paris Saclay University Pierre Nicole Center, French Red Cross  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8291-5890","authenticated-orcid":false,"given":"Peter","family":"Vickerman","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4340-9995","authenticated-orcid":false,"given":"Hannah","family":"Fraser","sequence":"additional","affiliation":[{"name":"Population Health Sciences, Bristol Medical School University of Bristol  Bristol UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Weiss","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Lemoine","sequence":"additional","affiliation":[{"name":"Department of Metabolism, Digestion and Reproduction, Division of Digestive Diseases, Liver Unit Imperial College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Lacombe","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9, Inserm IPLESP, UMR\u2010S1136, Infectious Diseases Department Saint\u2010Antoine Hospital, AP\u2010HP  Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Don Des","family":"Jarlais","sequence":"additional","affiliation":[{"name":"School of Global Public Health New York University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2974-3484","authenticated-orcid":false,"given":"Pham Minh","family":"Khue","sequence":"additional","affiliation":[{"name":"Faculty of Public Health Hai Phong University of Medicine and Pharmacy  Hai Phong Vietnam"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Nagot","sequence":"additional","affiliation":[{"name":"Pathogenesis and Control of Chronic and Emerging Infections Universit\u00e9 de Montpellier, Inserm, Universit\u00e9 des Antilles,  Montpellier France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"\u201cGlobal Hepatitis Report 2024: Action for Access in Low\u2010 and Middle\u2010Income Countries \u201daccessed May 24 2024 https:\/\/www.who.int\/publications\u2010detail\u2010redirect\/9789240091672."},{"key":"e_1_2_9_3_1","unstructured":"\u201cCombating Hepatitis B and C to Reach Elimination by 2030 \u201daccessed May 24 2024 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of Viral 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