{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T23:08:35Z","timestamp":1793747315556,"version":"4.6.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T00:00:00Z","timestamp":1760313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study aimed to evaluate the status of hepatitis B virus (HBV) mother\u2010to\u2010child transmission (MTCT) among infants born to hepatitis B surface antigen (HBsAg)\u2010positive mothers from 2021 to 2023 and identify key factors influencing HBV MTCT, providing critical insights to inform future HBV prevention strategies. Data were obtained from the case records of HBsAg\u2010positive pregnant women and their newborns in Guangdong Province from January 1, 2021, to December 31, 2023. For HBsAg and anti\u2010HBs positive rates, bivariate analysis was conducted to examine associations between maternal and infant characteristics. Additionally, Firth's bias reduction logistic regression analysis was conducted to identify factors influencing MTCT. Our study analysed data from 131,781 HBsAg\u2010positive pregnant women and their newborns in Guangdong Province from 2021 to 2023. Among 131,781 infants completing PVST, the overall HBV MTCT rate was 0.44%, with an anti\u2010HBs positivity rate of 93.48%. Maternal age, administration of HepB\u2010BD and HBIG and use of antiviral treatment during pregnancy were significantly associated with HBV MTCT. However, birth weight, maternal education level, mode of delivery and number of births were not significantly associated with HBV MTCT risk. This study provides a comprehensive analysis of HBV MTCT among HBsAg\u2010positive pregnant women and their infants in Guangdong Province from 2021 to 2023. Despite significant advancements in HBV MTCT prevention, our findings underscore the need for enhanced strategies, particularly for pregnant women with high HBV viral loads. Strengthening maternal antiviral treatment, ensuring timely and comprehensive infant follow\u2010up, and implementing targeted health education programs will be essential for further reducing MTCT rates and improving long\u2010term outcomes.<\/jats:p>","DOI":"10.1111\/jvh.70094","type":"journal-article","created":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T01:19:40Z","timestamp":1760404780000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010World Study for Mother\u2010To\u2010Child Transmission of Hepatitis B in Guangdong Province, 2021\u20132023"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5204-5468","authenticated-orcid":false,"given":"Tiancheng","family":"Xie","sequence":"first","affiliation":[{"name":"Department of Laboratorial Science and Technology &amp; Vaccine Research Center, School of Public Health Peking University  Beijing P.R. China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Maternity Group Health Guangdong Women and Children Hospital  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Maternity Group Health Guangdong Women and Children Hospital  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianshuo","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Laboratorial Science and Technology &amp; Vaccine Research Center, School of Public Health Peking University  Beijing P.R. China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8347-3916","authenticated-orcid":false,"given":"Xiyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratorial Science and Technology &amp; Vaccine Research Center, School of Public Health Peking University  Beijing P.R. China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sihui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Laboratorial Science and Technology &amp; Vaccine Research Center, School of Public Health Peking University  Beijing P.R. China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Laboratorial Science and Technology &amp; Vaccine Research Center, School of Public Health Peking University  Beijing P.R. China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingsong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Laboratorial Science and Technology &amp; Vaccine Research Center, School of Public Health Peking University  Beijing P.R. China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Laboratorial Science and Technology &amp; Vaccine Research Center, School of Public Health Peking University  Beijing P.R. China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University  Beijing P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Maternity Group Health Guangdong Women and Children Hospital  Guangzhou P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuqiang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Laboratorial Science and Technology &amp; Vaccine Research Center, School of Public Health Peking University  Beijing P.R. 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