{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T10:52:39Z","timestamp":1780397559657,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004330","name":"GlaxoSmithKline","doi-asserted-by":"publisher","award":["212770"],"award-info":[{"award-number":["212770"]}],"id":[{"id":"10.13039\/100004330","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Characterisation of people with hepatitis B (PwHB) remains limited, particularly regarding treatment status, disease severity and biomarker profiles. Quantitative hepatitis B surface antigen (qHBsAg) is a key predictor of response to emerging therapies, but its distribution is poorly described. Using a large, ethnically diverse UK cohort, we assessed demographics, clinical features and HBsAg levels to guide treatment strategies. This cross\u2010sectional analysis of PwHB (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u20092000 [prespecified]) used data from four English hospitals, collected via the National Institute for Health and Care Research Health Informatics Collaborative framework. Individual characteristics were assessed overall, and\n                    <jats:italic>post hoc<\/jats:italic>\n                    by qHBsAg levels (\u2264\u20093000\/&gt;\u20093000\u2009IU\/mL; &lt;\u2009100\/\u2265\u2009100\u2013\u2264\u20091000\/&gt;\u20091000\u2009IU\/mL) available from one centre (\n                    <jats:italic>N<\/jats:italic>\n                    \u2009=\u2009457). The cohort had a slight male predominance (54%) and a mean age of 44.9\u2009years. White and Asian ethnicity each accounted for 25%, and 23% were on nucleos(t)ide analogue therapy. Centres collecting HBsAg data had more individuals with undetectable HBV DNA or on treatment. Among individuals with non\u2010missing qHBsAg data (263\/457), 167\/263 (63.5%) had qHBsAg \u2264\u20093000\u2009IU\/mL. These were older (49.6 vs. 43.5\u2009years), more likely to be male (53.9% vs. 35.4%), Asian (40.7% vs. 20.8%) or have undetectable HBV DNA (35.9% vs. 17.7%), and less likely to be Black (13.2% vs. 34.4%) versus those with qHBsAg &gt;\u20093000\u2009IU\/mL. Fifty\u2010six (21.3%) people had qHBsAg &lt;\u2009100\u2009IU\/mL, 60 (22.8%) between \u2265\u2009100 and \u2264\u20091000\u2009IU\/mL, and 147 (55.9%) &gt;\u20091000\u2009IU\/mL. This cohort of PwHB highlights qHBsAg distribution in clinical settings and could identify people more likely to achieve functional cure with emerging therapies.\n                  <\/jats:p>","DOI":"10.1111\/jvh.70101","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T10:20:17Z","timestamp":1763634017000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characterisation of People Living With Chronic Hepatitis B Virus Infection in England and Stratification by\n                    <scp>HBsAg<\/scp>\n                    Levels: A Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8994-2816","authenticated-orcid":false,"given":"Myriam","family":"Drysdale","sequence":"first","affiliation":[{"name":"GSK  London 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