{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T12:58:43Z","timestamp":1767013123894,"version":"3.48.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","award":["GrantID"],"award-info":[{"award-number":["GrantID"]}],"id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","award":["No.R.15012\/04\/2019\u2010HR\u2010VRDL"],"award-info":[{"award-number":["No.R.15012\/04\/2019\u2010HR\u2010VRDL"]}],"id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Hepatitis A virus (HAV), traditionally a paediatric illness in endemic regions, is now exhibiting an emerging age shift in symptomatic cases. This study investigates the sero\u2010molecular epidemiology of Hepatitis A in Puducherry and surrounding regions. Between January and November 2024, 513 acute viral hepatitis cases were evaluated for serum IgM anti\u2010HAV. Representative samples underwent sequencing and B\u2010cell epitope analysis. Of the 150 patients (29.23%) tested positive for HAV, children under 12\u2009years (50%) were most affected, with an increasing trend in adult infection (31.33%), while adolescents aged 12\u201317\u2009years accounted for 18.66%. All viral strains were genotype IIIA with no major B\u2010cell epitope changes. A total of 732 asymptomatic individuals (2023\u20132024) were screened for IgG anti\u2010HAV across different age strata (1\u20135, 6\u201310, 11\u201315, 16\u201320 and 21\u201330\u2009years). The seroprevalence of HAV IgG varied by age: 1\u20135\u2009years (58.5%), 6\u201310\u2009years (52.87%), 11\u201315\u2009years (44.95%), 16\u201320\u2009years (56.88%) and 21\u201330\u2009years (83.16%). Hepatitis A remains a significant health concern in Puducherry and its surrounding regions, with symptomatic infections occurring more frequently in children, followed by adults. However, HAV seroprevalence was higher in young adults and comparatively lower in children and adolescents.<\/jats:p>","DOI":"10.1111\/jvh.70104","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T13:03:52Z","timestamp":1764767032000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Understanding the Serologic and Molecular Epidemiology of Hepatitis A Infection in Puducherry and Surrounding Regions of India"],"prefix":"10.1111","volume":"33","author":[{"given":"Haripriya","family":"Sivakumar","sequence":"first","affiliation":[{"name":"Department of Microbiology, JIPMER  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8984-3332","authenticated-orcid":false,"given":"Rahul","family":"Dhodapkar","sequence":"additional","affiliation":[{"name":"Department of Microbiology, JIPMER  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Palanivel","family":"Chinnakali","sequence":"additional","affiliation":[{"name":"Department of Preventive and Social Medicine, JIPMER  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2058-2672","authenticated-orcid":false,"given":"Ferdinamarie Sharmila","family":"Philomenadin","sequence":"additional","affiliation":[{"name":"Department of Microbiology, JIPMER  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ratchagadasse Vimal","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Microbiology, JIPMER  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nivedha","family":"Devanathan","sequence":"additional","affiliation":[{"name":"Department of Microbiology, JIPMER  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_14_2_1","unstructured":"World Health Organization \u201cPrevention and Control of Viral Hepatitis Infection: Framework for Global Action \u201d World Health Organization (2012) https:\/\/www.who.int\/publications\/i\/item\/prevention\u2010and\u2010control\u2010of\u2010viral\u2010hepatitis\u2010infection\u2010framework\u2010for\u2010global\u2010action."},{"key":"e_1_2_14_3_1","article-title":"Age Group\u2010Specific Assessment of Changing Seroepidemiology of Hepatitis A Virus Infection in North India","volume":"14","author":"Agarwal J.","year":"2022","journal-title":"Cureus"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-73-6-1365"},{"volume-title":"National Action Plan Combating Viral Hepatitis in India","year":"2019","author":"National Health Mission","key":"e_1_2_14_5_1"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/jehp.jehp_1005_22"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v4.i3.68"},{"key":"e_1_2_14_8_1","unstructured":"S. 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