{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T12:58:42Z","timestamp":1767013122756,"version":"3.48.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T00:00:00Z","timestamp":1765411200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AA029545"],"award-info":[{"award-number":["P01 AA029545"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U24 AA020794"],"award-info":[{"award-number":["U24 AA020794"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AA020799"],"award-info":[{"award-number":["U01 AA020799"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The degree to which alcohol use is associated with the risk of all\u2010cause mortality and hepatic decompensation after hepatitis C (HCV) diagnosis, treatment, and cure remains unknown. We sought to address this question among patients achieving sustained virologic response (SVR) after direct\u2010acting antiviral treatment in the largest HCV health system in the United States. We extracted data on alcohol use, HCV treatment, SVR, HIV co\u2010infection, demographics, risk behaviours, hepatic decompensation, and mortality from all patients in the 1945 to 1965 VA Birth Cohort. Alcohol use categories were generated using responses to the Alcohol Use Disorders Identification Test\u2013Consumption (AUDIT\u2010C) questionnaire and diagnostic codes for alcohol use disorder (AUD): abstinent without a history of AUD, abstinent with a history of AUD, current lower\u2010risk consumption, current moderate\u2010risk consumption, and current high\u2010risk consumption with or without AUD. Cox proportional hazard models were used to examine associations between alcohol category and the risk of hepatic decompensation and all\u2010cause mortality. Among 50,581 patients in the analytic cohort, compared to current drinkers exhibiting lower risk alcohol consumption (referent), current high\u2010risk consumption with or without AUD was associated with increased risk of all\u2010cause mortality (aHR: 1.40, 95% CI: 1.21\u20131.63) and hepatic decompensation (HR: 2.15, 95% CI: 1.60\u20132.89) as was abstinence with a history of AUD diagnosis (mortality aHR: 1.63, 95% CI: 1.41\u20131.89; hepatic decompensation aHR: 1.85, 95% CI: 1.36\u20132.51). AUD and high\u2010risk alcohol consumption are associated with the risk of hepatic decompensation and all\u2010cause mortality among Veterans who have achieved SVR, including those categorised as being currently abstinent. Interventions for alcohol consumption and use disorder among individuals treated for HCV infection may reduce morbidity and mortality in this population.<\/jats:p>","DOI":"10.1111\/jvh.70116","type":"journal-article","created":{"date-parts":[[2025,12,11]],"date-time":"2025-12-11T09:30:02Z","timestamp":1765445402000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Prior and Current Unhealthy Alcohol Use and Liver Morbidity Risk and Mortality Among Veterans With a History of Hepatitis C Who Have Achieved Sustained Virological Response"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6617-4992","authenticated-orcid":false,"given":"Jonathan","family":"Feelemyer","sequence":"first","affiliation":[{"name":"Department of Population Health New York University School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francois Kaoon","family":"Ban","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ronald Scott","family":"Braithwaite","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Debika","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"UCLA Health  Los Angeles California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ellen C.","family":"Caniglia","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy C.","family":"Justice","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"},{"name":"VA Connecticut Healthcare System  West Haven Connecticut USA"},{"name":"Yale School of Public Health  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1126-8128","authenticated-orcid":false,"given":"Joseph K.","family":"Lim","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7955-0600","authenticated-orcid":false,"given":"Vincent Lo","family":"Re","sequence":"additional","affiliation":[{"name":"Perelman School of Medicine, University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joy","family":"Scheidell","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University School of Medicine  New York New York USA"},{"name":"Department of Health and Sciences University of Central Florida  Orlando Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher T.","family":"Rentsch","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"},{"name":"VA Connecticut Healthcare System  West Haven Connecticut USA"},{"name":"Faculty of Epidemiology and Population Health London School of Hygiene &amp; Tropical Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Population Health New York University School of Medicine  New York New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,12,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2012.09.009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510270132"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr6902a1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1316366"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61036-9"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S132072"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29419"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2022-074001"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/155.4.323"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.12367"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/acer.13204"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.22010"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12290"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.07.027"},{"issue":"11","key":"e_1_2_10_16_1","first-page":"1473","article-title":"HIV\u2010HCV Co\u2010Infection: Epidemiology, Pathogenesis and Therapeutic Implications","volume":"16","author":"Andreoni M.","year":"2012","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/milmed\/167.9.756"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9629(15)40773-6"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01854.x"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00127-003-0639-y"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.13423"},{"key":"e_1_2_10_22_1","unstructured":"SAMHSA Center for Behavioral Health Statistics and Quality \u201cNational Survey on Drug Use and Health \u201d(2019) Table\u00a05.4B\u2014Alcohol Use Disorder in Past Year Among Persons Aged 12 or Older by Age Group and Demographic Characteristics: Percentages 2018 and 2019."},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13-1133"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27366"},{"issue":"2","key":"e_1_2_10_25_1","first-page":"154","article-title":"Concordance of Sustained Virologic Response at Weeks 4, 12 and 24 Post\u2010Treatment of Hepatitis c in the Era of New Oral Direct\u2010Acting Antivirals: A Concise Review","volume":"15","author":"Burgess S. 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