{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:16:16Z","timestamp":1787015776038,"version":"build-2736575974"},"reference-count":57,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatitis D virus (HDV) screening rates in the United States are low. We evaluated the impact of double reflex\u2010based HDV testing on HDV\u2010related morbidity and mortality in the United States. A Screen and Treat model simulated the HDV screening cascade (decision tree) and assessed the natural history of HDV (Markov model) over a 5\u2010year time horizon from a United States third\u2010party payer perspective, for patients positive for HBV. The number of patients diagnosed with HDV and liver\u2010related outcomes were compared under double reflex screening (100% patients screened for HDV antibodies and HDV RNA) and current practice (11% patients screened for HDV antibodies and 25% anti\u2010HDV\u2010positive patients for HDV RNA). Implementation of HDV double reflex testing predicted a 3655% increase in patients diagnosed versus current practice (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u20097231 vs.\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009193, respectively). The number of predicted occurrences of all liver\u2010related outcomes over 5\u2009years is lower with double reflex testing versus current practice (difference in numbers of events: \u22127% for compensated cirrhosis, \u221240% for decompensated cirrhosis, \u221223% for hepatocellular carcinoma, \u221234% for liver transplantation, and \u221232% for liver\u2010related deaths). Results of scenario analyses with varying HBV prevalence, treatment received, or treatment rates were similar. Simulation of double reflex testing predicted earlier detection of HDV patients, increased numbers of patients diagnosed and treated, and reduced rates of disease progression, liver\u2010related complications and deaths. These findings highlight the need for implementing strategies to improve HDV screening and linkage to care and treatment in the United States.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.clinicaltrials.gov\">ClinicalTrials.gov<\/jats:ext-link>\n                    identifier: NCT03852719\n                  <\/jats:p>","DOI":"10.1111\/jvh.70119","type":"journal-article","created":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T14:01:16Z","timestamp":1765980076000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of Double Reflex Testing and Linkage to Treatment on Clinical Outcomes of Chronic Hepatitis Delta Virus Infection in the United States"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-6092-2541","authenticated-orcid":false,"given":"Robert J.","family":"Wong","sequence":"first","affiliation":[{"name":"Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6306-3189","authenticated-orcid":false,"given":"Robert G.","family":"Gish","sequence":"additional","affiliation":[{"name":"Hepatitis B Foundation  Doylestown Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ira M.","family":"Jacobson","sequence":"additional","affiliation":[{"name":"New York University Grossman School of Medicine  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph K.","family":"Lim","sequence":"additional","affiliation":[{"name":"Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marvin","family":"Rock","sequence":"additional","affiliation":[{"name":"HEOR\u2014Global Value and Access, Gilead Sciences, Inc.  Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csilla","family":"Kinyik\u2010Merena","sequence":"additional","affiliation":[{"name":"Maple Health Group  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanxiao","family":"Ma","sequence":"additional","affiliation":[{"name":"Maple Health Group  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9215-8109","authenticated-orcid":false,"given":"Nathaniel","family":"Smith","sequence":"additional","affiliation":[{"name":"Maple Health Group  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4728-9038","authenticated-orcid":false,"given":"Chong","family":"Kim","sequence":"additional","affiliation":[{"name":"HEOR\u2014Global Value and Access, Gilead Sciences, Inc.  Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-023-10575-0"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz633"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000642"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2023.100818"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-023-07960-y"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000687"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15921"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15579"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14833"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.14309\/ajg.0000000000001947"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13779"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/hc9.0000000000000401"},{"key":"e_1_2_8_15_1","unstructured":"R.Wong R. 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