{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T14:59:58Z","timestamp":1772981998229,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82070611"],"award-info":[{"award-number":["82070611"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515220029"],"award-info":[{"award-number":["2021A1515220029"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023B03J1287"],"award-info":[{"award-number":["2023B03J1287"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004000","name":"Guangzhou Municipal Science and Technology Program key projects","doi-asserted-by":"publisher","award":["2023B01J1007"],"award-info":[{"award-number":["2023B01J1007"]}],"id":[{"id":"10.13039\/501100004000","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010256","name":"Guangzhou Municipal Science and Technology Project","doi-asserted-by":"publisher","award":["202102010204"],"award-info":[{"award-number":["202102010204"]}],"id":[{"id":"10.13039\/501100010256","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    The optimal strategy for chronic hepatitis B virus (HBV) infected patients with negative hepatitis B e\u2010antigen (HBeAg) and normal alanine aminotransferase (ALT) remains uncertain. This study aimed to evaluate the safety and efficacy of tenofovir alafenamide fumarate (TAF) treatment in this patient population. This prospective, open\u2010label, randomised controlled trial enrolled HBeAg\u2010negative patients with normal ALT and randomised them 1:1 to either the treatment group (TAF) or the control group (no treatment). The primary endpoint was the reduction in hepatitis B surface antigen (HBsAg) levels from baseline to week 48. A total of 62 patients were enrolled and followed up by 48\u2009weeks (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200931 per group). No serious adverse events were reported. At week 48, there was no significant difference in the change in HBsAg between the treatment and control groups [0.01 (\u22120.06, 0.05) vs. \u22120.05 (\u22120.12, 0.06) log\n                    <jats:sub>10<\/jats:sub>\n                    IU\/mL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.354]. However, HBV DNA levels were significantly lower in the treatment group (0 vs. 2.86 log\n                    <jats:sub>10<\/jats:sub>\n                    IU\/mL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.001). All patients achieved HBV DNA below 20\u2009IU\/mL after treatment. Additionally, chitinase\u20103\u2010like protein 1 level was lower in the treatment group (23.8 vs. 44.8\u2009ng\/mL,\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.019). TAF was well\u2010tolerated in HBeAg\u2010negative patients with normal ALT and low\u2010level HBV DNA viremia. Treatment for 48\u2009weeks led to a high rate of HBV DNA suppression and may potentially delay liver fibrosis progression. Accordingly, early antiviral treatment may benefit this patient population.\n                  <\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration:<\/jats:bold>\n                    Clinical trial number: NCT 04231565\n                  <\/jats:p>","DOI":"10.1111\/jvh.70141","type":"journal-article","created":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T09:58:21Z","timestamp":1769680701000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Tenofovir Alafenamide Fumarate Reduces Virological Replication in\n                    <scp>HBeAg<\/scp>\n                    \u2010Negative Patients With Normal Alanine Aminotransferase: A 48\u2010Week Randomised Controlled Trial"],"prefix":"10.1111","volume":"33","author":[{"given":"Qiumin","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Infectious Disease The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0671-697X","authenticated-orcid":false,"given":"Wenxiong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeqiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangyong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xingrong","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou 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