{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T15:00:05Z","timestamp":1772982005731,"version":"3.50.1"},"reference-count":35,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The Strategic Plan for Tackling Hepatitis C launched by the Ministry of Health in 2015 led to an important nationwide decrease in chronic hepatitis C\u2010related hospitalisation rates by 2018 (25.8% of decrease compared to 2014 rates). This work aims to actualize the results on hepatitis C hospitalisation burden in Spain until 2023. Chronic HCV\u2010related hospitalisation discharges from 2014 to 2023 were obtained from the Registry of Specialised Health Activity. A descriptive analysis of the hospitalisations was performed. All chronic, advanced liver disease (AdLD), and non\u2010AdLD (N\u2010AdLD) hospitalisation rates (HRs) were calculated at national and regional level. Hospitalisation rate ratios using 2014 as reference year were calculated using a Poisson model. From 2014 to 2023 there were 374,222 chronic HCV\u2010related hospitalisations: 267,920 (71.6%) with N\u2010AdLD and 106,302 (28.4%) with AdLD. Overall in\u2010hospital fatality rate was 6.8%. In 2023, compared to 2014, national HRs decreased 49.7% (95% CI: 49.0% to 50.4%) for all chronic, 43.3% (95% CI: 42.4% to 44.3%) for N\u2010AdLD and 62.6% (95% CI: 61.5% to 63.6%) for AdLD. At regional level, 10\/19 Spanish regions achieved a decrease in the HRs of &gt;\u200940%\u201360% and 1\/19 of &gt;\u200960%\u201380% for N\u2010AdLD. For AdLD, 14\/19 of the regions achieved a decrease in the HRs of &gt;\u200960% (one of them, Ceuta, &gt;\u200980% of decrease) and 3\/19 a decrease of &gt;\u200940%\u201360%. Following the implementation of the Strategic Plan, the hospital burden due to chronic HCV has continuously decreased in Spain. By 2023, the hospitalisation rate for chronic cases has been reduced to half.<\/jats:p>","DOI":"10.1111\/jvh.70143","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:27:21Z","timestamp":1769599641000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Direct\u2010Acting Antivirals Availability on Hepatitis C\u2010Related Hospitalisations After Eight Years of the Strategic Plan for Tackling Hepatitis C Implementation in Spain"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4064-3823","authenticated-orcid":false,"given":"Macarena","family":"Garrido\u2010Estepa","sequence":"first","affiliation":[{"name":"Instituto de Salud Carlos III (ISCIII)  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00472-6"},{"key":"e_1_2_11_3_1","volume-title":"Strategic Plan for Tackling Hepatitis C in the Spanish National Health System","year":"2015"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3851\/IMP3061"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12879-015-0748-8"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29814"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40261-018-0624-6"},{"key":"e_1_2_11_8_1","article-title":"10\u2009Years of the Strategic Plan for Tackling Hepatitis C in the Spanish National Health System (PEAHC): A National Project for the Elimination of Hepatitis C as a Public Health Problem","volume":"99","author":"Del Amo Valero J.","year":"2025","journal-title":"Revista Espa\u00f1ola de Salud P\u00fablica"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.07.027"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurpub\/ckab069"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13491"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000001841"},{"key":"e_1_2_11_13_1","article-title":"Outcomes of Direct\u2010Acting Antivirals Versus Interferon\u2010Based Therapy in Chronic Hepatitis C Infection","volume":"16","author":"Chowdhury R.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijms.43079"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2018.11.024"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12945"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0186213"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.03.004"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.11.011"},{"key":"e_1_2_11_20_1","unstructured":"C.Thomadakis I.Gountas K.Gountas et\u00a0al. \u201cEstimation of the Prevalence of Chronic Hepatitis C in Spain \u201d12th Panhellenic Meeting on AIDS Hepatitis Emerging Diseases and Addictions (9\/2024)."},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32237"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciac928"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastrohep.2022.01.002"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13708"},{"key":"e_1_2_11_25_1","unstructured":"C. A.Rivero \u201cAn\u00e1lisis y Desarrollo de los GDR en el Sistema Nacional de Salud \u201d(Ministerio de Sanidad 2016) https:\/\/www.sanidad.gob.es\/estadEstudios\/estadisticas\/docs\/analisis.pdf."},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aohep.2021.100568"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2016.06.015"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-323663"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.soc.2023.06.007"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/v16121899"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13659"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhepr.2025.101336"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2015.21.2.105"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1157\/13090276"},{"key":"e_1_2_11_35_1","unstructured":"\u201cEl Sistema Nacional de Salud atendi\u00f3 cerca del 80% de los ingresos hospitalarios en 2022 \u201dMinisterio de Sanidad accessed June 2 2025 https:\/\/www.sanidad.gob.es\/gabinete\/notasPrensa.do?id=6594."},{"key":"e_1_2_11_36_1","unstructured":"\u201cEstad\u00edstica de Centros de Atenci\u00f3n Especializada. A\u00f1o 2022 \u201d(Ministerio de Sanidad 2022) accessed June 2 2025 https:\/\/www.sanidad.gob.es\/estadEstudios\/estadisticas\/docs\/TablasSIAE2022\/2022_INFORME_ANUAL_SIAE.pdf."}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.70143","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.70143","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.70143","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T08:36:05Z","timestamp":1772958965000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.70143"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,28]]},"references-count":35,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1111\/jvh.70143"],"URL":"https:\/\/doi.org\/10.1111\/jvh.70143","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,28]]},"assertion":[{"value":"2025-06-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-19","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-28","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70143"}}