{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T16:46:08Z","timestamp":1790009168658,"version":"4.0.1"},"reference-count":37,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Inequitable access to HCV treatment persists, particularly for rural and marginalised populations. Synchronous telemedicine (TM) could mitigate access barriers, but its comparative effectiveness versus in\u2010person care is uncertain. We performed a systematic review and meta\u2010analysis comparing synchronous TM with in\u2010person care for HCV. The primary outcome was sustained virologic response (SVR); secondary outcomes were treatment initiation and completion. Subgroup analyses examined study design, therapy era (interferon vs. direct\u2010acting antivirals [DAAs]), and setting (rural vs. non\u2010rural). Narrative synthesis addressed people who use drugs (PWUD), incarcerated populations, pandemic\u2010era cohorts, and economic evaluations. Fifteen studies involving 7.459 patients (2 RCTs, 13 observational) were included (13 meta\u2010analysed). For SVR, the pooled effect showed no significant difference between interventions (odds ratio [OR] 1.60, 95% CI 0.69\u20133.68). Treatment initiation and completion were also not significantly different overall (initiation OR 7.59, 95% CI 0.79\u201372.81; completion OR 2.50, 95% CI 0.76\u20138.25), although exclusion of single influential studies yielded significant benefits for TM in sensitivity analyses. Subgroups suggested context\u2010specific advantages: TM favoured SVR in rural settings (OR\u2009=\u20094.19, 95% CI 1.28\u201313.73) and in RCTs (OR\u2009=\u200910.42, 95% CI 7.41\u201314.67). Narrative evidence indicated that TM improved linkage and cure among PWUD and incarcerated individuals, preserved efficacy during COVID\u201019, and reduced costs. Overall, synchronous TM seems comparable to in\u2010person care overall and may be superior in rural and marginalised populations.<\/jats:p>","DOI":"10.1111\/jvh.70144","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:30:58Z","timestamp":1769599858000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Synchronous Telemedicine Versus In\u2010Person Care in Hepatitis C Treatment: A Systematic Review and Meta\u2010Analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"Igor Boechat","family":"Silveira","sequence":"first","affiliation":[{"name":"Universidade Federal de Juiz de Fora  Juiz de Fora Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Proc\u00f3pio","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Roraima  Roraima Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Victor de Holanda","family":"Sampaio","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas  Macei\u00f3 Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milena Ramos","family":"Tom\u00e9","sequence":"additional","affiliation":[{"name":"Universidade Federal de Campina Grande  Cajazeiras Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingying Elena","family":"Chen","sequence":"additional","affiliation":[{"name":"Universidade Idomed Vista Carioca  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alana Vit\u00f3ria Santos","family":"de Jesus","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia  Salvador Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7824-2152","authenticated-orcid":false,"given":"Guilherme Grossi Lopes","family":"Can\u00e7ado","sequence":"additional","affiliation":[{"name":"Hospital das Cl\u00ednicas da Universidade Federal de Minas Gerais  Belo Horizonte Brazil"},{"name":"Hospital da Pol\u00edcia Militar de Minas Gerais  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,28]]},"reference":[{"issue":"6","key":"e_1_2_9_2_1","first-page":"626","article-title":"Hepatitis C: Diagnosis and Management","volume":"104","author":"Maness D. 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