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We conducted a cross\u2010sectional study in 16 prisons across Eastern Denmark between October 2022 and August 2024, enrolling 651 incarcerated individuals. All participants underwent HCV antibody and RNA testing using dried blood spots and completed a bio\u2010behavioural risk survey. The prevalence of HCV antibody and HCV RNA was 4.2% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200926) and 2.0% (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200913) respectively. HCV exposure was most prevalent among individuals with a history of injecting drug use (56.4%), women (11.3%) and foreign\u2010born individuals (6.7%). In multivariable logistic regression, HCV exposure was significantly associated with injecting drug use (adjusted odds ratio [aOR] 209.11, 95% confidence interval [CI]: 36.16\u20131209.27), female sex (male vs. female: aOR 0.18, 95% CI: 0.05\u20130.60) and being born in a low\u2010prevalence country (aOR 6.22, 95% CI: 1.64\u201323.61). We observed substantial site\u2010level variation and care gaps that disproportionately affect marginalised groups. These findings support the implementation of targeted HCV screening at prison intake, along with facility\u2010specific and population\u2010tailored interventions, as essential strategies for achieving Denmark's commitment to the World Health Organization's HCV elimination goal.\n                  <\/jats:p>","DOI":"10.1111\/jvh.70154","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:25:55Z","timestamp":1772969155000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Prevalence and Factors Associated With Hepatitis C in Danish Prisons, 2022\u20132024: A Multicentre Cross\u2010Sectional Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-4140","authenticated-orcid":false,"given":"Jonas","family":"Demant","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital  Hvidovre 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Strunge","family":"Nilsson","sequence":"additional","affiliation":[{"name":"Department of Clinical Microbiology Copenhagen University Hospital  Hvidovre Denmark"},{"name":"Department of Clinical Microbiology Copenhagen University Hospital  Herlev Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ditte Andersen","family":"Skovdal","sequence":"additional","affiliation":[{"name":"Health Team, Danish Prison and Probation Service  K\u00f8benhavn \u00d8 Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina","family":"Weis","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Copenhagen University Hospital  Hvidovre Denmark"},{"name":"Department of Clinical Medicine, Faculty of Health and Medical Sciences University of Copenhagen  Copenhagen 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