{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T22:51:42Z","timestamp":1787611902639,"version":"build-2736575974"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T00:00:00Z","timestamp":1773014400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Hepatitis E virus (HEV) is a leading cause of acute viral hepatitis worldwide. Whereas HEV infection is typically self\u2010limiting, rare cases of prolonged cholestasis have been reported. The underlying mechanisms remain unclear, though host genetic variation may contribute. This study aimed to investigate the role of genetic predisposition in HEV\u2010induced prolonged cholestasis by analysing variants in genes associated with hepatocanalicular transport. We performed a retrospective review of medical records from three university centres in Switzerland and Germany and identified five immunocompetent patients with prolonged cholestasis following acute HEV infections. Genetic analysis using next\u2010generation sequencing included a panel of five genes involved in cholestatic liver diseases (\n                    <jats:italic>ATP8B1, ABCB11<\/jats:italic>\n                    ,\n                    <jats:italic>ABCB4, ABCC2<\/jats:italic>\n                    and\n                    <jats:italic>MYO5B<\/jats:italic>\n                    ). Variant frequencies were evaluated using population reference databases and compared with a genetically characterised cohort of asymptomatic HEV\u2010infected blood donors. All five patients were male, with a median age of 59\u2009years. The median duration of cholestasis exceeded 77\u2009days. Two patients exhibited potentially pathogenic heterozygous variants:\n                    <jats:italic>ATP8B1<\/jats:italic>\n                    p.N45T in one patient and\n                    <jats:italic>MYO5B<\/jats:italic>\n                    p.K429R in another. Additionally, common\n                    <jats:italic>ABCB11<\/jats:italic>\n                    variants were detected in all patients, which might have contributed to cholestatic clinical presentation. In the asymptomatic HEV\u2010infected controls, the\n                    <jats:italic>MYO5B<\/jats:italic>\n                    p.K429R variant was absent, whereas the\n                    <jats:italic>ATP8B1<\/jats:italic>\n                    p.N45T variant was detected in only one individual in a heterozygous state. These case series illustrate that host genetics might influence the severity of HEV infection, particularly prolonged cholestatic jaundice. Further research is needed to explore the interaction between viral infections and host genetics in liver disorders.\n                  <\/jats:p>","DOI":"10.1111\/jvh.70156","type":"journal-article","created":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:43:33Z","timestamp":1773049413000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prolonged Intrahepatic Cholestasis After Acute Hepatitis E Infection: A Case Series and Genetic Analysis"],"prefix":"10.1111","volume":"33","author":[{"given":"Montserrat","family":"Fraga","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3693-2827","authenticated-orcid":false,"given":"Sophie","family":"Kasmi","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Lausanne University Hospital and University of Lausanne  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susanne N.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Medicine II Saarland University Medical Center, Saarland University  Homburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman","family":"Liebe","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Transplant Medicine, Medical Faculty University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Sempoux","sequence":"additional","affiliation":[{"name":"Institute of Pathology Lausanne University Hospital and University of Lausanne  Lausanne 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University Medical Center, Saarland University  Homburg Germany"},{"name":"Department of Medicine Knappschaftsklinikum Saar  P\u00fcttlingen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Lammert","sequence":"additional","affiliation":[{"name":"Center for Health Economics Research Hannover (CHERH) Hannover Medical School (MHH)  Hannover Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcin","family":"Krawczyk","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Hepatology and Transplant Medicine, Medical Faculty University of Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5048-390X","authenticated-orcid":false,"given":"Christoph","family":"J\u00fcngst","sequence":"additional","affiliation":[{"name":"Department of Medicine II Saarland University Medical Center, Saarland University  Homburg Germany"},{"name":"Department of Gastroenterology and Hepatology University Hospital Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,9]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.86"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14468"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(11)61849-7"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e32834ca4da"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15704"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2015.0039"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-200111000-00017"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0b013e328209414d"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2017.10.022"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000701"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.4254\/wjh.v17.i4.92426"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11626-x"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201355"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/350690"},{"issue":"1","key":"e_1_2_9_16_1","first-page":"195","article-title":"Functional 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