{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,6]],"date-time":"2026-04-06T00:06:09Z","timestamp":1775433969443,"version":"3.50.1"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T00:00:00Z","timestamp":1773100800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Universal infant hepatitis B (HBV) vaccination is highly effective in preventing infection. However, little is known about whether a mother's HBV vaccination history influences her child's immune response to routine immunisation. We aimed to compare vaccine\u2010induced antibody responses in children of vaccinated and unvaccinated mothers. We conducted a historical\u2010retrospective cohort study of 364 children who completed the standard infant HBV vaccination series and underwent post\u2010vaccination antibody testing. Maternal vaccination status was determined by serology, medical records and cohort year. Children were classified as offspring of HBsAg\u2010negative vaccinated mothers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200992), HBsAg\u2010negative unvaccinated mothers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u2009174), or HBsAg\u2010positive mothers (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200998), who also received hepatitis B immunoglobulin (HBIG) at birth. Anti\u2010HBs titers were analysed and categorised. Ordinal logistic regression was used to assess associations. Overall seroprotection rates (\u2265\u200910\u2009mIU\/mL) were high (89.3%) and did not differ significantly between groups. However, children born to mothers vaccinated prior to pregnancy were significantly more likely to achieve very high antibody levels (\u2265\u20091000\u2009mIU\/mL) compared with children of unvaccinated mothers or those who received HBIG at birth (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05). This association was most pronounced in children tested at \u2264\u20093\u2009years of age. Mean anti\u2010HBs titers were also highest in offspring of vaccinated mothers. While older maternal age and lower haemoglobin levels impaired the response, the HBIG did nothing. While infant HBV seroprotection rates were uniformly high regardless of maternal background, children born to mothers vaccinated against HBV prior to pregnancy exhibited a more robust early antibody response (\u2265\u20091000\u2009mIU\/mL). These findings suggest a possible intergenerational enhancement of vaccine responsiveness and may affect long\u2010term implications for HBV vaccination strategies.\n                  <\/jats:p>","DOI":"10.1111\/jvh.70165","type":"journal-article","created":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T10:37:04Z","timestamp":1773139024000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Hepatitis B Vaccine Response in Children of Vaccinated Versus Unvaccinated Mothers: A Retrospective Cohort Study"],"prefix":"10.1111","volume":"33","author":[{"given":"Safa","family":"Shibli","sequence":"first","affiliation":[{"name":"The Liver Institute, Hadassah Medical Organization, Hadassah Medical School The Hebrew University  Jerusalem Israel"},{"name":"School of Public Health University of Haifa  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohamad","family":"Suki","sequence":"additional","affiliation":[{"name":"The Liver Institute, Hadassah Medical Organization, Hadassah Medical School The Hebrew University  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tannous","family":"Korzom","sequence":"additional","affiliation":[{"name":"Clalit Health Services  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred S.","family":"Green","sequence":"additional","affiliation":[{"name":"School of Public Health University of Haifa  Haifa Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rifaat","family":"Safadi","sequence":"additional","affiliation":[{"name":"The Liver Institute, Hadassah Medical Organization, Hadassah Medical School The Hebrew University  Jerusalem Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,3,10]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"WHO \u201cHepatitis B \u201d2024 https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/hepatitis\u2010b."},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/17455057241235881"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468\u20101253(18)30056\u20106"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1086\/314578"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.307.6899.276"},{"issue":"8590","key":"e_1_2_9_7_1","first-page":"875","article-title":"Immunisation Against Hepatitis 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