{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T17:24:29Z","timestamp":1790097869997,"version":"4.0.1"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic hepatitis C virus infection (HCV) is one of the leading causes of hepatocellular carcinoma (HCC) in the United States. Using a retrospective cross\u2010sectional analysis, this study identified patient characteristics and factors associated with the development of HCV\u2010associated HCC in 113 patients seen in the primary care\u2010based HCV clinic in Grady Memorial Hospital, a public, safety\u2010net healthcare facility in Atlanta, Georgia from October 2013 to November 2024. The study population was comprised of mostly African American men with high rates of polysubstance use, 96.5% of whom had cirrhosis. Patients treated for HCV prior to HCC diagnosis were older at HCC diagnosis (mean difference 3.248,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value 0.037), had a longer latency period between HCV and HCC diagnoses (mean difference 38.740,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value 0.002), had prior HCC screening (mean difference 0.547,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value 0.000), and less time from last HCC screening to HCC diagnosis (mean difference \u221225.332,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value 0.012), and had a lower Child\u2010Pugh Score at time of HCC diagnosis (mean difference \u22120.300,\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value 0.036) compared to patients who were not treated for HCV. For patients who achieved SVR prior to HCC, HCV genotype 1 was associated with longer time to HCC diagnosis (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value 0.030), and a higher FIB\u20104 index at the time of achieving SVR and longer knowledge of HCV infection were associated with shorter time to developing HCC (\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value 0.003;\n                    <jats:italic>p<\/jats:italic>\n                    \u2010value 0.044). Ultimately, this study highlights the importance of understanding risk factors for HCV\u2010associated HCC in underserved populations which could help providers tailor their approach to mitigate the risk of HCC.\n                  <\/jats:p>","DOI":"10.1111\/jvh.70169","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:31:18Z","timestamp":1773819078000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Characteristics of Patients and Factors Associated With the Development of Hepatitis C Virus\u2010Associated Hepatocellular Carcinoma in an Urban, Primary\u2010Care Based Hepatitis C Clinic"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7728-5644","authenticated-orcid":false,"given":"Kathryn","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Medicine Emory University School of Medicine  Atlanta Georgia 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