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This study evaluates the cost\u2010effectiveness of interventions aimed at improving long\u2010term monitoring and retention in care among diagnosed CHB. A Markov model simulated outcomes for a cohort of 100,000 adults, comparing current practice to three interventions: EHR\u2010based provider reminders, patient navigators and a combined strategy. Costs and quality\u2010adjusted life years (QALYs) were evaluated from a healthcare perspective. All interventions were cost\u2010effective, with weighted incremental cost\u2010effectiveness ratios (US$\/QALY) of US$8069 (EHR reminders), US$8416 (Patient Navigators) and US$8608 (Combined). Compared with current practice, a combined strategy would avert 1670 cases of compensated cirrhosis, 738 cases of decompensated cirrhosis, 1011 cases of hepatocellular carcinoma, 188 liver transplants, and 2058 CHB\u2010related deaths in a cohort of 100,000. Structured interventions to improve CHB monitoring can deliver substantial health gains at modest costs. These findings can support policy initiatives to improve CHB care retention and highlight the importance of tailoring interventions to local healthcare capacity and population needs.<\/jats:p>","DOI":"10.1111\/jvh.70176","type":"journal-article","created":{"date-parts":[[2026,4,13]],"date-time":"2026-04-13T05:05:29Z","timestamp":1776056729000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cost\u2010Effectiveness of Interventions to Improve Retention in Care for Chronic Hepatitis B in the United States"],"prefix":"10.1111","volume":"33","author":[{"given":"Irene","family":"Starinieri","sequence":"first","affiliation":[{"name":"Department of Health Technology Assessment, Erasmus School of Health Policy and Management Erasmus University  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amit","family":"Chitnis","sequence":"additional","affiliation":[{"name":"Alameda County Public Health Department Division of Communicable Disease Control and Prevention  San Leandro California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6092-2541","authenticated-orcid":false,"given":"Robert J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"Yette","sequence":"additional","affiliation":[{"name":"Alameda County Public Health Department Division of Communicable Disease Control and Prevention  San Leandro California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang","family":"Pham","sequence":"additional","affiliation":[{"name":"Asian Liver Center Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy S.","family":"Tang","sequence":"additional","affiliation":[{"name":"North East Medical Services  San Francisco California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"So","sequence":"additional","affiliation":[{"name":"Asian Liver Center Stanford University School of Medicine  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehlika","family":"Toy","sequence":"additional","affiliation":[{"name":"Department of Health Technology Assessment, Erasmus School of Health Policy and Management Erasmus University  Rotterdam the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,12]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"U.S. Department of Health and Human Services \u201cHepatitis B Basics [Internet] \u201d (2019) https:\/\/www.hhs.gov\/hepatitis\/learn\u2010about\u2010viral\u2010hepatitis\/hepatitis\u2010b\u2010basics\/index.html."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31782"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw516"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/HC9.0000000000000118"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001549"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6921a2"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0313898"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciab405"},{"key":"e_1_2_10_10_1","volume-title":"A National Strategy for the Elimination of Hepatitis B and C: Phase Two Report [Internet]","author":"Committee on a National Strategy for the Elimination of Hepatitis B and C, Board on Population Health and Public Health Practice, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine","year":"2017"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2016.02.011"},{"issue":"10","key":"e_1_2_10_12_1","first-page":"633","article-title":"Liver Disease in Women: The Influence of Gender on Epidemiology, Natural History, and Patient Outcomes","volume":"9","author":"Guy J.","year":"2013","journal-title":"Gastroenterology & Hepatology (New York, N.Y.)"},{"key":"e_1_2_10_13_1","volume-title":"Age and Gender\u2010Specific Disease Progression Rates to Cirrhosis and Hepatocellular Carcinoma in Treated and Untreated Patients With Chronic Hepatitis B","author":"Le A.","year":"2017"},{"key":"e_1_2_10_14_1","unstructured":"\u201cOPTN: Organ Procurement and Transplantation Network \u201d (1992) http:\/\/optn.transplant.hrsa.gov\/latestData\/viewDataReports.asp."},{"key":"e_1_2_10_15_1","first-page":"261","article-title":"Can Primary Care Health Centers Manage Chronic Hepatitis B? 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