{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:26:07Z","timestamp":1790011567327,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,10]],"date-time":"2026-05-10T00:00:00Z","timestamp":1778371200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic hepatitis delta (CHD) is the most severe form of viral hepatitis and is associated with accelerated progression to cirrhosis and liver failure. Bulevirtide has shown promising results in trials, but real\u2010world data on its effectiveness, safety and impact on patient\u2010reported outcomes (PROs) remain limited. To evaluate the effectiveness, safety, and PROs (quality\u2010of life\u2014QoL; adherence) of bulevirtide therapy in CHD patients undergoing a dedicated pharmacist\u2010led patient\u2010education program (PEP). A prospective observational study enrolled 31 consecutive CHD patients receiving bulevirtide 2\u2009mg daily at a tertiary referral centre. Virological, biochemical and combined responses were assessed at weeks 24, 48 and 60. QoL (through EQ\u20105D\u20105L questionnaire), adherence (proportion of days covered), and adverse events were monitored during follow\u2010up. Bulevirtide significantly reduced HDV\u2010RNA by week 24 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01), with further reductions at week 48 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.05) and 60 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Liver tests improved significantly from baseline to week 24 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and remained stable. Combined response was achieved in 43.7% of patients by week 60. QoL improved significantly (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.03), and adherence was excellent (\u2265\u200990%). Adverse events were mostly mild and transient. In real\u2010world clinical practice, bulevirtide achieved sustained virological and biochemical improvements with favourable safety and quality\u2010of\u2010life outcomes, confirming its effectiveness in routine management of CHD. While the 60\u2010week data (\n                    <jats:italic>n<\/jats:italic>\n                    \u2009=\u200916) are exploratory due to the sample size, these findings confirm its effectiveness and safety in routine management of CHD.\n                  <\/jats:p>","DOI":"10.1111\/jvh.70181","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T04:21:08Z","timestamp":1778473268000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Effectiveness, Safety and Patient\u2010Reported Outcomes of Bulevirtide Therapy in Chronic Hepatitis Delta: Real\u2010World Evidence From a Prospective Observational Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1374-1505","authenticated-orcid":false,"given":"Daniele","family":"Mengato","sequence":"first","affiliation":[{"name":"Hospital Pharmacy Department Azienda Ospedale\u2010Universit\u00e0 Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Battistella","sequence":"additional","affiliation":[{"name":"Gastroenterology and Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology Azienda Ospedale\u2010Universit\u00e0 Padova, University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Cadore","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical and Pharmacological Sciences University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabetta Mariavittoria","family":"Giunco","sequence":"additional","affiliation":[{"name":"Hospital Pharmacy Department Azienda Ospedale\u2010Universit\u00e0 Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Zanaga","sequence":"additional","affiliation":[{"name":"Gastroenterology and Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology Azienda Ospedale\u2010Universit\u00e0 Padova, University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Zappitelli","sequence":"additional","affiliation":[{"name":"Gastroenterology and Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology Azienda Ospedale\u2010Universit\u00e0 Padova, University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonietta","family":"Romano","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Tonon","sequence":"additional","affiliation":[{"name":"Unit of Internal Medicine and Hepatology (UIMH), Department of Medicine University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Pasin","sequence":"additional","affiliation":[{"name":"General Medicine and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine Azienda Ospedale\u2010Universit\u00e0 Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Barbaro","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit Azienda Ospedale\u2010Universit\u00e0 Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lolita","family":"Sasset","sequence":"additional","affiliation":[{"name":"Infectious and Tropical Diseases Unit Azienda Ospedale\u2010Universit\u00e0 Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Scribano","sequence":"additional","affiliation":[{"name":"Gastroenterology Unit S. Antonio Hospital, Azienda Ospedale\u2010Universit\u00e0 Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Gambato","sequence":"additional","affiliation":[{"name":"Gastroenterology and Multivisceral Transplant Unit, Department of Surgery, Oncology and Gastroenterology Azienda Ospedale\u2010Universit\u00e0 Padova, University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacomo","family":"Berti","sequence":"additional","affiliation":[{"name":"Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, Vascular Sciences, and Public Health University of Padova  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paolo","family":"Simioni","sequence":"additional","affiliation":[{"name":"General Medicine and Thrombotic and Hemorrhagic Diseases Unit, Department of Medicine Azienda Ospedale\u2010Universit\u00e0 Padova  Padua 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