{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T05:46:15Z","timestamp":1782452775804,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100005564","name":"Gilead Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005564","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The epidemiological landscape of paired hepatitis B virus (HBV)\/hepatitis delta virus (HDV) genotype (GT) among patients with HDV in the US remains unknown. HBV\/HDV genotypes were assessed in two independent US cohorts: Cohort 1 included 5222 HBV\u2010positive patients from Quest Diagnostics, including 114 anti\u2010HDV+ patients; Cohort 2 included 178 anti\u2010HDV+ samples from highly phenotyped patients managed at the National Institutes of Health (NIH). HBV\/HDV sequencing and genotyping were analysed using phylogenetic analyses. In the overall cohort, HBV and HDV genotypes were determined for 197 (67%) and 139 (48%) patients, respectively, with HDV GT1 and GT5 and paired HBV\/HDV genotypes D\/1 and A\/1 being the most prevalent. The most frequent HBV genotypes were GTD (40%) and GTA (35%), and the most frequent HDV genotypes were GT1 (84%) and GT5 (13%). Among 111 paired HBV\/HDV genotypes, D\/1 (50%) and A\/1 (26%) were most common. In Cohort 2, 77 (79%) patients with HDV GT1 were foreign\u2010born, most commonly Mongolian\u2010born (47\/77, 61%), while 21% (20\/77) were US\u2010born. Among patients with HDV GT5, GT6, or GT7, 93% (14\/15) were of African origin. Overall, these findings provide the first comprehensive US analysis of HBV\/HDV paired genotypes among patients with HDV and indicate that HBV genotype distributions differ between HBV\/HDV coinfection and HBV monoinfection.<\/jats:p>","DOI":"10.1111\/jvh.70186","type":"journal-article","created":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T08:58:10Z","timestamp":1780563490000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genotypes of Hepatitis B and D Viruses Among Patients With Hepatitis D in the United States"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0918-151X","authenticated-orcid":false,"given":"Andrew","family":"Lopez","sequence":"first","affiliation":[{"name":"Gilead Sciences Inc  Foster City California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harish","family":"Gopalakrishna","sequence":"additional","affiliation":[{"name":"Liver 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