{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T12:05:34Z","timestamp":1779883534287,"version":"3.53.1"},"reference-count":36,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Fatigue in chronic viral hepatitis may be associated with decreased health\u2010related quality of life and other patient\u2010reported outcomes (PROs). We evaluated the relationship between fatigue and PROs in patients with chronic hepatitis B (CHB) and chronic hepatitis C (CHC). Patients with CHB and CHC enrolled in the Global Liver Registry completed PRO instruments: FACIT\u2010F, CLDQ (for CHB), CLDQ\u2010HCV (for CHC), and WPAI:SHP. Fatigue was defined as FACIT\u2010F Fatigue Scale (FS) score\u2009&lt;\u200930 (scale range: 0\u201352). Among 2888 patients from 14 countries, 1561 had CHB (mean age 47\u2009\u00b1\u200913\u2009years; 60% male; 13% advanced fibrosis; 13% depression; 17% fatigue) and 1327 had CHC (50\u2009\u00b1\u200913\u2009years; 47% male; 21% advanced fibrosis; 18% depression; 28% fatigue). CHB\u2010fatigue was associated with younger age, female, obesity, anxiety, depression (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01) and worse PRO scores: CLDQ (scale 1\u20137): 4.1\u2009\u00b1\u20090.9 vs. 5.8\u2009\u00b1\u20090.9; FACIT score (range 0\u2013108): 67.6\u2009\u00b1\u200914.5 vs. 87.7\u2009\u00b1\u200913.7; work productivity impairment (range 0\u20131): 0.33\u2009\u00b1\u20090.29 vs. 0.11\u2009\u00b1\u20090.22 (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). Multivariable analysis confirmed the association of fatigue with lower PRO scores, impairment up to \u221223% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). CHC\u2010fatigue was associated with female sex, obesity, type 2 diabetes, anxiety, depression (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.05) and worse PRO scores: CLDQ\u2010HCV: 3.8\u2009\u00b1\u20091.0 vs. 5.5\u2009\u00b1\u20091.0; FACIT: 61.8\u2009\u00b1\u200914.1 vs. 85.6\u2009\u00b1\u200914.5; work productivity impairment: 0.49\u2009\u00b1\u20090.32 vs. 0.17\u2009\u00b1\u20090.25 (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.0001). In multivariable models, fatigue remained associated with reduced PRO scores, impairment up to \u221233% (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&lt;\u20090.01). Almost one in five patients with chronic viral hepatitis report significant fatigue, which is associated with substantial PRO and work productivity impairment. Routine assessment for and management of fatigue in CHC or CHB care is essential.\n                  <\/jats:p>","DOI":"10.1111\/jvh.70188","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T05:39:44Z","timestamp":1779082784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Impact of Fatigue on Patient\u2010Reported Outcomes and Work Productivity in Chronic Hepatitis B and C: Insights From a Multinational Registry Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4518-5283","authenticated-orcid":false,"given":"Yusuf","family":"Yilmaz","sequence":"first","affiliation":[{"name":"The Global Liver and Global NASH\/MASH Councils  Washington District of Columbia USA"},{"name":"Department of Gastroenterology School of Medicine, Recep Tayyip Erdo\u011fan University  Rize T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-1900","authenticated-orcid":false,"given":"Ming\u2010Lung","family":"Yu","sequence":"additional","affiliation":[{"name":"The Global Liver and Global NASH\/MASH Councils  Washington District of Columbia USA"},{"name":"Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3521-8523","authenticated-orcid":false,"given":"Khalid","family":"Alswat","sequence":"additional","affiliation":[{"name":"The Global Liver and Global NASH\/MASH Councils  Washington District of Columbia USA"},{"name":"King Saud University  Riyadh Saudi 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