{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T12:18:21Z","timestamp":1787833101242,"version":"build-2784847793"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T00:00:00Z","timestamp":1786665600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Chronic hepatitis B (CHB) and hepatitis D virus (HDV) coinfection are major causes of cirrhosis and hepatocellular carcinoma. The geographic distribution of CHB and alignment of anti\u2010HDV testing with CHB burden remain poorly defined. We aimed to examine if anti\u2010HDV testing and seropositivity align with areas of highest CHB burden. Adults with CHB (2014\u20132022) were identified using a validated serologic algorithm in the provincial laboratory database capturing HBV\/HDV serology. Cases were geolocated to Aggregate Dissemination Areas (ADAs), linked to Alberta Health Services zones and rural\u2013urban continuum levels. Age\u2010 and sex\u2010standardized CHB prevalence was calculated per ADA using the 2016 Canadian Census. Descriptive mapping, global spatial autocorrelation and local hotspot analysis were used to assess spatial clustering. Among 8317 persons with CHB, the provincial age\u2010 and sex\u2010standardized prevalence was 1.70 per 1000 population (95% CI, 1.66\u20131.74). Prevalence ranged from 2.15 per 1000 in metropolitan areas to 0.40 per 1000 in remote regions and was higher in Calgary than Edmonton (2.53 vs. 1.73 per 1000). Overall, 17.5% of CHB patients were tested for anti\u2010HDV, and 4.1% of those tested were anti\u2010HDV positive. CHB prevalence hotspots were concentrated in metropolitan ADAs, whereas hotspots of anti\u2010HDV testing and positivity showed only partial overlap with these high\u2010burden areas. CHB burden in Alberta is geographically clustered, particularly within specific neighbourhoods of metropolitan cities, whereas anti\u2010HDV testing remains infrequent and only partially aligned with high\u2010burden areas. Reflex or systematic anti\u2010HDV testing, paired with geographically informed outreach, may improve case detection.<\/jats:p>","DOI":"10.1111\/jvh.70223","type":"journal-article","created":{"date-parts":[[2026,8,14]],"date-time":"2026-08-14T17:04:40Z","timestamp":1786727080000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Geospatial Discrepancy of Chronic Hepatitis B and Hepatitis D Testing in Alberta: A Population\u2010Based Spatial Analysis"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-5053-9006","authenticated-orcid":false,"given":"Bryce","family":"Tkachuk","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Cumming, School of Medicine, University of Calgary  Calgary Alberta 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