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This study analyses the burden and risk factors associated with viral hepatitis at global, regional, and national levels from 1990 to 2021, and projects the disease burden from 2022 to 2046. From 1990 to 2021, the global burden of viral hepatitis increased, despite a decline in age\u2010standardized rates. Population growth emerged as the primary driver influencing this trend, with the highest disease burden observed in the African region. A high body\u2010mass index (BMI) demonstrated a distinct and significant association with the sustained increase in disease burden. Excessive alcohol consumption was identified as the leading cause of hepatitis B, while drug abuse was predominantly linked to hepatitis C. Notably, males exhibited a markedly higher susceptibility to these risk factors compared to females. Over the next 25\u2009years, the disease burden of hepatitis A, B, C and E is projected to remain stable or decline. Viral hepatitis remains a significant global public health challenge. It is imperative to strengthen efforts to prevent alcohol and drug abuse, consistently advance disease detection and treatment methods, and enable low\u2010 and middle\u2010income countries to improve healthcare infrastructure and expand vaccination coverage. These measures are essential to promptly reduce the disease burden and achieve the goal of eliminating viral hepatitis by 2030.<\/jats:p>","DOI":"10.1111\/jvh.70236","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T13:17:10Z","timestamp":1790860630000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Global, Regional and National Burden of Viral Hepatitis From 1990 to 2021 With Forecasts to 2046: Findings From the Global Burden of Disease Study 2021"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-1636-1244","authenticated-orcid":false,"given":"Jiyuan","family":"Ren","sequence":"first","affiliation":[{"name":"National Demonstration Center for Experimental Basic Medical Science Education Xuzhou Medical University  Xuzhou Jiangsu PR China"},{"name":"Jiangsu Key Laboratory of Immunity and Metabolism Xuzhou Medical University  Xuzhou Jiangsu PR 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