{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:53:20Z","timestamp":1791179600394,"version":"4.1.0"},"reference-count":32,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T00:00:00Z","timestamp":1791072000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003653","name":"Korea National Institute of Health","doi-asserted-by":"publisher","award":["2025\u2010ER1904\u201000"],"award-info":[{"award-number":["2025\u2010ER1904\u201000"]}],"id":[{"id":"10.13039\/501100003653","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Physical activity (PA) confers several health benefits; however, whether increasing PA among physically inactive adults with chronic hepatitis B (CHB) is associated with lower risks of adverse clinical outcomes remains unclear. We used the nationwide Korean National Health Insurance database. We included 318,131 adults with CHB who were physically inactive at the initial health screening (Exam 1) and completed a subsequent screening within 4\u2009years (Exam 2). Among them, 58,703 initiated moderate\u2010to\u2010vigorous PA (MVPA), defined as vigorous activity \u2265\u200920\u2009min\/day on \u2265\u20093\u2009days\/week or moderate activity \u2265\u200930\u2009min\/day on \u2265\u20095\u2009days\/week. The primary outcome was all\u2010cause mortality, and the secondary outcomes were liver\u2010related events (hepatic decompensation, liver transplantation, hepatocellular carcinoma [HCC]) and HCC. Multivariable Cox and Fine\u2013Grey competing\u2010risk models were adjusted for demographic, clinical, and behavioural factors. During a median 7.9\u2010year follow\u2010up (IQR, 5.2\u20139.5), 7609 deaths occurred. MVPA initiation was associated with lower all\u2010cause mortality (hazard ratio [HR], 0.89; 95% CI, 0.84\u20130.94), a lower risk of liver\u2010related events (subdistribution HR [subHR], 0.94; 95% CI, 0.92\u20130.97), and, more modestly, of HCC (subHR, 0.95; 95% CI, 0.91\u20130.99) compared with those remaining inactive. The association was more pronounced in older adults, women, never smokers, non\u2010drinkers, and untreated participants (all p for interaction \u2264\u20090.03). Initiating MVPA among physically inactive adults with CHB was associated with lower risks of mortality and liver\u2010related outcomes. These findings provide large\u2010scale epidemiological evidence supporting further evaluation of PA promotion in physically inactive patients with CHB.<\/jats:p>","DOI":"10.1111\/jvh.70240","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:21:52Z","timestamp":1791177712000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Becoming Physically Active and Risks of Mortality and Liver\u2010Related Events in Adults With Chronic Hepatitis B: A Nationwide Cohort Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9418-7846","authenticated-orcid":false,"given":"Byeong Geun","family":"Song","sequence":"first","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7185-9471","authenticated-orcid":false,"given":"Myeongcheol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Design and Evaluation SAIHST, Sungkyunkwan University  Seoul South Korea"},{"name":"Center for Clinical Epidemiology, Samsung Medical Center Sungkyunkwan University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9081-0266","authenticated-orcid":false,"given":"Juhee","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Design and Evaluation SAIHST, Sungkyunkwan University  Seoul South Korea"},{"name":"Center for Clinical Epidemiology, Samsung Medical Center Sungkyunkwan University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6453-3450","authenticated-orcid":false,"given":"Geum\u2010Youn","family":"Gwak","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0244-7714","authenticated-orcid":false,"given":"Danbee","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Clinical Research Design and Evaluation SAIHST, Sungkyunkwan University  Seoul South Korea"},{"name":"Center for Clinical Epidemiology, Samsung Medical Center Sungkyunkwan University  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-5554","authenticated-orcid":false,"given":"Dong Hyun","family":"Sinn","sequence":"additional","affiliation":[{"name":"Department of Medicine, Samsung Medical Center Sungkyunkwan University School of Medicine  Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,4]]},"reference":[{"issue":"10","key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S2468-1253(23)00197-8","article-title":"Global Prevalence, Cascade of Care, and Prophylaxis Coverage of Hepatitis B in 2022: A Modelling Study","volume":"8","author":"Polaris Observatory Collaborators","year":"2023","journal-title":"Lancet Gastroenterology & Hepatology"},{"issue":"1","key":"e_1_2_10_3_1","first-page":"62","article-title":"Changing Etiology and Epidemiology of Hepatocellular Carcinoma: Asia and Worldwide","volume":"24","author":"Kim D. 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Gastrointestinal and Liver Physiology"},{"issue":"11","key":"e_1_2_10_33_1","article-title":"Liver Disease\u2010Related Sarcopenia: A Predictor of Poor Prognosis by Accelerating Hepatic Decompensation in Advanced Chronic Liver Disease","volume":"15","author":"Nakamura A.","year":"2023","journal-title":"Cureus"}],"container-title":["Journal of Viral Hepatitis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.70240","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jvh.70240","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jvh.70240","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T05:21:57Z","timestamp":1791177717000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jvh.70240"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,4]]},"references-count":32,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["10.1111\/jvh.70240"],"URL":"https:\/\/doi.org\/10.1111\/jvh.70240","archive":["Portico"],"relation":{},"ISSN":["1352-0504","1365-2893"],"issn-type":[{"value":"1352-0504","type":"print"},{"value":"1365-2893","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,4]]},"assertion":[{"value":"2026-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-23","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-10-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70240"}}