{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:40:23Z","timestamp":1792478423814,"version":"4.5.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T00:00:00Z","timestamp":1792368000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal of Viral Hepatitis"],"published-print":{"date-parts":[[2026,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Data on potential differences in hepatocellular carcinoma (HCC) incidence between entecavir (ETV) and tenofovir alafenamide (TAF) in chronic hepatitis B (CHB) patients are limited. This retrospective multinational study included treatment\u2010na\u00efve adults with CHB without a history of HCC who initiated ETV or TAF therapy since 2016 at 23 centres in 4 countries. Baseline characteristics were balanced using inverse probability of treatment weighting (IPTW) and propensity score matching (PSM). HCC incidence and the association between antiviral regimen and HCC were analysed using competing\u2010risk analysis. A total of 1437 patients (710 ETV, 727 TAF) were included, with similar mean follow\u2010up durations (55.5\u2009\u00b1\u200929.8 vs. 58.0\u2009\u00b1\u200925.5\u2009months;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.077). ETV\u2010treated patients were older, more frequently male, and more likely to have cirrhosis. After IPTW, both groups had balanced characteristics (all standardised differences &lt;\u20090.1). After IPTW adjustment, during follow\u2010up, 23 patients on ETV and 20 on TAF developed HCC, with incidence rates of 0.67 and 0.65 per 100 person\u2010years, respectively (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.853). There was no statistically significant difference in HCC risk between the groups (SHR: 1.09; 95% CI: 0.44\u20132.65;\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.851), with consistent findings across subgroups by age, sex, cirrhosis, hepatic steatosis, HBeAg, baseline liver enzymes, HBV DNA levels, diabetes mellitus and in sensitivity analysis using PSM. In this real\u2010world multinational study of treatment\u2010na\u00efve CHB patients, HCC incidence did not significantly differ between ETV and TAF groups, suggesting therapeutic selection should consider cost and patient\u2010specific factors.\n                  <\/jats:p>","DOI":"10.1111\/jvh.70250","type":"journal-article","created":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T06:02:28Z","timestamp":1792476148000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Similar Long\u2010Term Incidence of Hepatocellular Carcinoma in Chronic Hepatitis B Initiating Entecavir Versus Tenofovir Alafenamide: A\n                    <scp>REAL<\/scp>\n                    \u2010B Study"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-1352","authenticated-orcid":false,"given":"Haruki","family":"Uojima","sequence":"first","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Stanford University Medical Center  Palo Alto California USA"},{"name":"Department of Gastroenterology, Internal Medicine Kitasato University School of Medicine  Sagamihara Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Huang","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Stanford University Medical Center  Palo Alto California USA"},{"name":"Department of Infectious Disease Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huy","family":"Trinh","sequence":"additional","affiliation":[{"name":"San Jose Gastroenterology  San Jose California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3310-6632","authenticated-orcid":false,"given":"Akito","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Gastroenterological Center, Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Vutien","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology University of Washington  Seattle Washington USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1652-6168","authenticated-orcid":false,"given":"Hidenori","family":"Toyoda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Ogaki Municipal Hospital  Ogaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Honda","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1106-9524","authenticated-orcid":false,"given":"Hiroshi","family":"Abe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Shinmatsudo Central General Hospital  Chiba Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3374-7111","authenticated-orcid":false,"given":"Masanori","family":"Atsukawa","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology Nippon Medical School  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7659-914X","authenticated-orcid":false,"given":"Tsunamasa","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology St. Marianna University School of Medicine  Kawasaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5470-9694","authenticated-orcid":false,"given":"Toru","family":"Ishikawa","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology Saiseikai Niigata Hospital  Niigata Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4028-4381","authenticated-orcid":false,"given":"Masaru","family":"Enomoto","sequence":"additional","affiliation":[{"name":"Department of Hepatology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"},{"name":"Department of Transfusion Medicine Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2473-6966","authenticated-orcid":false,"given":"Yasuhito","family":"Tanaka","sequence":"additional","affiliation":[{"name":"Department of Virology and Liver Unit Nagoya City University Graduate School of Medical Sciences  Nagoya Japan"},{"name":"Department of Gastroenterology and Hepatology, Faculty of Life Sciences Kumamoto University  Kumamoto Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0175-8721","authenticated-orcid":false,"given":"Koichi","family":"Takaguchi","sequence":"additional","affiliation":[{"name":"Department of Hepatology Kagawa Prefectural Central Hospital  Takamatsu Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5044-6727","authenticated-orcid":false,"given":"Pei\u2010Chien","family":"Tsai","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2376-421X","authenticated-orcid":false,"given":"Wan\u2010Long","family":"Chuang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Hepatitis Research Center, College of Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Center for Metabolic Disorders and Obesity, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2296-3054","authenticated-orcid":false,"given":"Chia\u2010Yen","family":"Dai","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Hepatitis Research Center, College of Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Center for Metabolic Disorders and Obesity, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2752-7051","authenticated-orcid":false,"given":"Jee\u2010Fu","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Hepatitis Research Center, College of Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Center for Metabolic Disorders and Obesity, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3367-068X","authenticated-orcid":false,"given":"Chung\u2010Feng","family":"Huang","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Hepatitis Research Center, College of Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Center for Metabolic Disorders and Obesity, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3728-7618","authenticated-orcid":false,"given":"Ming\u2010Lun","family":"Yeh","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Hepatitis Research Center, College of Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Center for Metabolic Disorders and Obesity, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomonori","family":"Senoh","sequence":"additional","affiliation":[{"name":"Department of Hepatology Kagawa Prefectural Central Hospital  Takamatsu Kagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6946-5082","authenticated-orcid":false,"given":"Mayumi","family":"Maeda","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Stanford University Medical Center  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0211-7013","authenticated-orcid":false,"given":"Ramsey","family":"Cheung","sequence":"additional","affiliation":[{"name":"Gastroenterology and Hepatology The Palo Alto Veterans Affairs Health Care System  Palo Alto California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2594-0854","authenticated-orcid":false,"given":"Takanori","family":"Ito","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Nagoya University Graduate School of Medicine  Nagoya Aichi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7576-7187","authenticated-orcid":false,"given":"Manabu","family":"Morimoto","sequence":"additional","affiliation":[{"name":"Gastroenterological Center, Yokohama City University Medical Center  Yokohama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8145-1900","authenticated-orcid":false,"given":"Ming\u2010Lung","family":"Yu","sequence":"additional","affiliation":[{"name":"Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital Kaohsiung Medical University  Kaohsiung Taiwan"},{"name":"Hepatitis Research Center, College of Medicine, Kaohsiung Medical University  Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1657-010X","authenticated-orcid":false,"given":"Chao","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University  Nanjing Jiangsu China"},{"name":"Institute of Viruses and Infectious Diseases, Nanjing University  Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6275-4989","authenticated-orcid":false,"given":"Mindie H.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Division of Gastroenterology and Hepatology, Department of Medicine Stanford University Medical Center  Palo Alto California USA"},{"name":"Department of Epidemiology and Population Health Stanford University  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,10,19]]},"reference":[{"key":"e_1_2_12_2_1","unstructured":"World Health Organization \u201cHepatitis B \u201d(2021) https:\/\/www.who.int\/news\u2010room\/fact\u2010sheets\/detail\/hepatitis\u2010b."},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jhep.2019.05.017","article-title":"Residual Risk of HCC During Long\u2010Term Oral Nucleos(t)ide Analogues (NUCs) in Patients With CHB \u2013 Is One NUC Better Than the Other?","volume":"7","author":"Wong G. L.\u2010H.","year":"2019","journal-title":"Journal of Hepatology"},{"key":"e_1_2_12_4_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1053\/j.gastro.2014.03.048","article-title":"Association of Nucleos(t)ide Analogue Therapy With Reduced Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B: A Nationwide Cohort Study","volume":"147","author":"Wu C. Y.","year":"2014","journal-title":"Gastroenterology"},{"key":"e_1_2_12_5_1","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1002\/hep.29800","article-title":"Update on Prevention, Diagnosis, and Treatment of Chronic Hepatitis B: AASLD 2018 Hepatitis B Guidance","volume":"67","author":"Terrault N. A.","year":"2018","journal-title":"Hepatology"},{"key":"e_1_2_12_6_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S0140-6736(22)01468-4","article-title":"Hepatitis B","volume":"401","author":"Jeng W. J.","year":"2023","journal-title":"Lancet"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00535-020-01698-4","article-title":"An Expert Review on the Use of Tenofovir Alafenamide for the Treatment of Chronic Hepatitis B Virus Infection in Asia","volume":"55","author":"Charlton M. R.","year":"2020","journal-title":"Journal of Gastroenterology"},{"key":"e_1_2_12_8_1","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12072-019-10005-0","article-title":"Tenofovir Versus Entecavir in Lowering the Risk of Hepatocellular Carcinoma Development in Patients With Chronic Hepatitis B: A Critical Systematic Review and Meta\u2010Analysis","volume":"14","author":"Li M.","year":"2020","journal-title":"Hepatology International"},{"key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/S2468-1253(20)30249-1","article-title":"Hepatocellular Carcinoma Incidence With Tenofovir Versus Entecavir in Chronic Hepatitis B: A Systematic Review and Meta\u2010Analysis","volume":"5","author":"Tseng C. H.","year":"2020","journal-title":"Lancet Gastroenterology & Hepatology"},{"key":"e_1_2_12_10_1","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1007\/s12072-020-10080-8","article-title":"Is Tenofovir More Effective Than Entecavir to Prevent Hepatocellular Carcinoma? The Controversy Goes on","volume":"14","author":"Tseng C. H.","year":"2020","journal-title":"Hepatology International"},{"key":"e_1_2_12_11_1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.14309\/ajg.0000000000000428","article-title":"Tenofovir Versus Entecavir for Hepatocellular Carcinoma Prevention in an International Consortium of Chronic Hepatitis B","volume":"115","author":"Hsu Y. C.","year":"2020","journal-title":"American Journal of Gastroenterology"},{"key":"e_1_2_12_12_1","doi-asserted-by":"crossref","DOI":"10.1002\/jgh3.70055","article-title":"Switching to Tenofovir Therapy Versus Continuation of Entecavir for Patients With Hepatitis B Virus Infection: A Systematic Review and Meta\u2010Analysis","volume":"8","author":"Shahzil M.","year":"2024","journal-title":"JGH Open"},{"key":"e_1_2_12_13_1","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1089\/aid.2017.0203","article-title":"Superior Efficacy and Improved Renal and Bone Safety After Switching From a Tenofovir Disoproxil Fumarate\u2010 To a Tenofovir Alafenamide\u2010Based Regimen Through 96\u2009Weeks of Treatment","volume":"34","author":"DeJesus E.","year":"2018","journal-title":"AIDS Research and Human Retroviruses"},{"key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S2468-1253(19)30421-2","article-title":"Switching From Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Virologically Suppressed Patients With Chronic Hepatitis B: A Randomised, Double\u2010Blind, Phase 3, Multicentre Non\u2010Inferiority Study","volume":"5","author":"Lampertico P.","year":"2020","journal-title":"Lancet Gastroenterology & Hepatology"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1111\/apt.18278","article-title":"Eight\u2010Year Efficacy and Safety of Tenofovir Alafenamide for Treatment of Chronic Hepatitis B Virus Infection: Final Results From Two Randomised Phase 3 Trials","volume":"60","author":"Buti M.","year":"2024","journal-title":"Alimentary Pharmacology & Therapeutics"},{"key":"e_1_2_12_16_1","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000030630","article-title":"Switching to Tenofovir Alafenamide Versus Continued Therapy in Chronic Hepatitis B Patients Who Were Treated With Entecavir: A Prospective, Multicenter, Randomized Controlled Study","volume":"101","author":"Sato K.","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"e_1_2_12_17_1","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1111\/liv.14786","article-title":"Switching From Entecavir to Tenofovir Alafenamide for Chronic Hepatitis B Patients With Low\u2010Level Viraemia","volume":"41","author":"Li Z. B.","year":"2021","journal-title":"Liver International"},{"key":"e_1_2_12_18_1","doi-asserted-by":"crossref","DOI":"10.1177\/2632010X241265858","article-title":"Short\u2010Term Efficacy of Tenofovir Alafenamide in Acute\u2010On\u2010Chronic Liver Failure: A Single Center Experience","volume":"17","author":"Li Z.","year":"2024","journal-title":"Clinical Pathology"},{"key":"e_1_2_12_19_1","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2023.1301120","article-title":"Comparative Effectiveness of Tenofovir Versus Entecavir in Patients With Hepatitis B Virus\u2010Related Cirrhosis in Taiwan: A Retrospective Cohort Study","volume":"14","author":"Huang Y. H.","year":"2023","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_12_20_1","first-page":"194","article-title":"Comparison of Tenofovir Alafenamide and Entecavir for Hepatitis B Virus\u2010Related Acute\u2010On\u2010Chronic Liver Failure","volume":"47","author":"Peng W.","year":"2022","journal-title":"Zhong Nan Da Xue Xue Bao. Yi Xue Ban"},{"key":"e_1_2_12_21_1","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2023.1185492","article-title":"Tenofovir Alafenamide Versus Entecavir for Treating Hepatitis B Virus\u2010Related Acute\u2010On\u2010Chronic Liver Failure: Real\u2010World Study","volume":"14","author":"Peng W.","year":"2023","journal-title":"Frontiers in Microbiology"},{"key":"e_1_2_12_22_1","first-page":"696","article-title":"Comparative Study of Treatment Outcome With Tenofovir Alafenamide and Entecavir in Patients With HBV Related Acute on Chronic Liver Failure","volume":"33","author":"Somon M. A. U.","year":"2024","journal-title":"Mymensingh Medical Journal"},{"key":"e_1_2_12_23_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2024.101268","article-title":"Lower Incidence of Hepatocellular Carcinoma With Tenofovir Alafenamide in Chronic Hepatitis B: Evidence From a Large\u2010Scale Cohort","volume":"7","author":"Yoo H. 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Y.","year":"2022","journal-title":"Hepatology International"},{"key":"e_1_2_12_26_1","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.jhep.2014.10.035","article-title":"Twenty\u2010Eight Day Safety, Antiviral Activity, and Pharmacokinetics of Tenofovir Alafenamide for Treatment of Chronic Hepatitis B Infection","volume":"62","author":"Agarwal K.","year":"2015","journal-title":"Journal of Hepatology"},{"key":"e_1_2_12_27_1","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.jhep.2024.08.028","article-title":"EASL Clinical Practice Guidelines on the Management of Hepatocellular Carcinoma","volume":"82","author":"European Association for the Study of the Liver","year":"2025","journal-title":"Journal of Hepatology"},{"key":"e_1_2_12_28_1","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1007\/s12072-024-10732-z","article-title":"APASL Clinical Practice Guidelines on Systemic Therapy for Hepatocellular Carcinoma\u20102024","volume":"18","author":"Lau G.","year":"2024","journal-title":"Hepatology International"},{"key":"e_1_2_12_29_1","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1007\/s12072-022-10411-x","article-title":"Effectiveness of Entecavir Versus Tenofovir Disoproxil Fumarate for Functional Cure of Chronic Hepatitis B in an International Cohort","volume":"16","author":"Hsu Y. 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