{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T19:16:03Z","timestamp":1792523763599,"version":"4.5.0"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Fibroblast growth factor 23 (FGF-23) is a phosphaturic hormone involved in the pathogenesis of secondary renal hyperparathyroidism (SRHP) in humans. There are no published studies examining feline FGF-23.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Validation of a method for FGF-23 quantification in feline plasma and assessment of the associations among plasma FGF-23, PTH, creatinine, and phosphate concentrations in cats with chronic kidney disease (CKD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>One hundred nonazotemic and azotemic geriatric (&amp;gt;9 years) client-owned cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cross-sectional study: Cats were categorized into 4 groups: control group (plasma creatinine (Cr) \u22642.0 mg\/dL), stage 2 (Cr 2.1\u20132.8 mg\/dL), stage 3 (Cr 2.9\u20135.0 mg\/dL), stage 4 (Cr &amp;gt;5.0 mg\/dL). Stages 2 and 3 were further subdivided based on International Renal Interest Society targets for plasma phosphate concentration (PO4): stage 2a (PO4 \u22644.5 mg\/dL), stage 2b (PO4 &amp;gt;4.5 mg\/dL), stage 3a (PO4 \u22645 mg\/dL), stage 3b (PO4 &amp;gt;5 mg\/dL). Plasma FGF-23 concentrations were measured by a human intact FGF-23 ELISA. Descriptive statistics and linear regression were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The ELISA demonstrated acceptable precision, reproducibility, and specificity. Plasma FGF-23 concentrations increased with increasing plasma creatinine concentrations and were significantly different between all groups (P &amp;lt; .008). Plasma FGF-23 concentrations were significantly higher in cats in stage 2b than stage 2a (P = .008) and in stage 3b than in stage 3a (P = .012). Phosphate, log creatinine, total calcium, log parathyroid hormone, and packed cell volume were all independent predictors of FGF-23.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>FGF-23 concentrations increase with increasing stage of feline CKD and might be a marker or mediator of feline SRHP.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12044","type":"journal-article","created":{"date-parts":[[2013,2,11]],"date-time":"2013-02-11T12:19:01Z","timestamp":1360585141000},"page":"234-241","source":"Crossref","is-referenced-by-count":83,"title":["Fibroblast Growth Factor 23 in Feline Chronic Kidney Disease"],"prefix":"10.1093","volume":"27","author":[{"given":"R.F.","family":"Geddes","sequence":"first","affiliation":[{"name":"Royal Veterinary College Department of Veterinary Clinical Sciences, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.C.","family":"Finch","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Veterinary Basic Sciences, , London,","place":["UK"]},{"name":"School of Veterinary Sciences, University of Bristol , Bristol,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Elliott","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Veterinary Basic Sciences, , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.M.","family":"Syme","sequence":"additional","affiliation":[{"name":"Royal Veterinary College Department of Veterinary Clinical Sciences, , Hatfield,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,3,1]]},"reference":[{"key":"2026020304243552300_jvim12044-bib-0001","first-page":"127","article-title":"Feline renal failure: Questions, answers, questions","volume":"14","author":"Lulich","year":"1992","journal-title":"Compend Cont Ed Pract Vet"},{"key":"2026020304243552300_jvim12044-bib-0002","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1748-5827.1998.tb03613.x","article-title":"Feline chronic renal failure: Calcium homeostasis in 80 cases diagnosed between 1992 and 1995","volume":"39","author":"Barber","year":"1998","journal-title":"J Small Anim Pract"},{"key":"2026020304243552300_jvim12044-bib-0003","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1056\/NEJM197205182862009","article-title":"On the pathogenesis of the uremic state. 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