{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T21:47:16Z","timestamp":1770155236490,"version":"3.49.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2013,3,1]],"date-time":"2013-03-01T00:00:00Z","timestamp":1362096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"American Academy of Veterinary Nutrition\u2013Waltham USA"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Feline hepatic lipidosis (HL) is associated with alterations in lipid and carbohydrate metabolism. The adipokines, adiponectin, and leptin have lipid-lowering and insulin-sensitizing effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Serum concentrations of adiponectin and leptin are altered in feline HL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Client-owned cats: 55 healthy and 45 with liver disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Cats with liver disease were categorized as having HL (n = 20), HL and concurrent disease (n = 19), or other liver disease (n = 6), based on clinical signs, laboratory findings, abdominal ultrasound examination as well as liver cytopathology, histopathology, or both. Serum samples were collected and body condition score determined.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean serum concentrations of adiponectin were higher in overweight cats with HL (4.5 \u03bcg\/mL), HL and concurrent disease (4.4 \u03bcg\/mL), or other liver disease (6.1 \u03bcg\/mL), as compared with healthy cats (1.5 \u03bcg\/mL; P &amp;lt; .001, P &amp;lt; .001, and P = .04, respectively). Mean serum concentration of leptin was higher in cats with HL (9.8 ng\/mL) or HL and concurrent disease (10.7 ng\/mL) than healthy cats (4.9 ng\/mL, P &amp;lt; .001 and P &amp;lt; .001, respectively). Cats with other liver disease had leptin concentration (4.9 ng\/mL) similar to healthy cats. Concentrations of adiponectin were correlated with alanine aminotransferase activity (r = 0.40, P = .0069), and concentrations of leptin were correlated with alkaline phosphatase activity (r = 0.42, P = .0051) in cats with liver disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Adipokine concentrations are altered in feline HL. Increased concentrations of adiponectin are related to liver disease, whereas increased concentrations of leptin are specifically related to HL.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12055","type":"journal-article","created":{"date-parts":[[2013,3,12]],"date-time":"2013-03-12T20:33:23Z","timestamp":1363120403000},"page":"242-249","source":"Crossref","is-referenced-by-count":11,"title":["Alterations in Adipokines in Feline Hepatic Lipidosis"],"prefix":"10.1093","volume":"27","author":[{"given":"M.","family":"Mazaki-Tovi","sequence":"first","affiliation":[{"name":"Diagnostic Center for Population and Animal Health Department of Pathobiology and Diagnostic Investigation, , East Lansing, MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.K.","family":"Abood","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Michigan State University Department of Small Animal Clinical Sciences, , East Lansing, 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