{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:42:16Z","timestamp":1791920536401,"version":"4.3.4"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2013,5,1]],"date-time":"2013-05-01T00:00:00Z","timestamp":1367366400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"UGA CaRES"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Administration of streptozotocin (STZ) at a 21-day interval has been described in dogs with stage II and III insulinoma. Myelosuppression was not observed, suggesting the possibility of increasing dose intensity by decreasing the interval between doses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe the tolerability of a biweekly STZ protocol. A secondary objective was to describe the outcome of dogs treated with this protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Nineteen dogs with residual local, metastatic, or recurrent insulinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>After surgery for insulinoma, or at the time of recurrence, dogs were treated with a previously described STZ and saline diuresis protocol. Treatments were administered every 14 days. All dogs received antiemetic treatment. Adverse events (AEs) were recorded and graded. Outcome endpoints assessed were progression-free survival (PFS) and survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>None of the dogs experienced neutropenia or thrombocytopenia. Mild to moderate gastrointestinal toxicity was the most common AE. Diabetes mellitus was observed in 8 dogs and, in 6, resulted in euthanasia or death. Two dogs developed nephrotoxicity manifested as Fanconi syndrome in 1 and nephrogenic diabetes insipidus in the other. Six dogs developed increased alanine amino transferase activity. Hypoglycemia at the end of the STZ infusion, resulted in collapse in 1 dog and a generalized seizure in another. The median overall PFS and survival time were 196 and 308 days, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Streptozotocin can be safely administered to dogs with insulinoma, but serious AEs are possible. Additional investigation is required to better define the role of STZ in managing dogs with insulinoma.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12086","type":"journal-article","created":{"date-parts":[[2013,4,18]],"date-time":"2013-04-18T16:24:03Z","timestamp":1366302243000},"page":"483-490","source":"Crossref","is-referenced-by-count":26,"title":["Prospective Evaluation of Biweekly Streptozotocin in 19 Dogs with Insulinoma"],"prefix":"10.1093","volume":"27","author":[{"given":"N.C.","family":"Northrup","sequence":"first","affiliation":[{"name":"University of Georgia, College of Veterinary Medicine Department of Small Animal Medicine and Surgery, , Athens, GA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Rassnick","sequence":"additional","affiliation":[{"name":"Cornell University, College of Veterinary Medicine Department of Clinical Sciences, , Ithaca, NY"},{"name":"Veterinary Medical Center of Central New York , East Syracuse, NY"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.L.","family":"Gieger","sequence":"additional","affiliation":[{"name":"University of Georgia, College of Veterinary Medicine Department of Small Animal Medicine and Surgery, , Athens, GA"},{"name":"Louisiana State University Veterinary Clinical Sciences Department, , Baton Rouge, LA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Kosarek","sequence":"additional","affiliation":[{"name":"University of Georgia, College of Veterinary Medicine Department of Small Animal Medicine and Surgery, , Athens, GA"},{"name":"Animal Cancer Care Clinic , Fort Lauderdale, FL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.W.","family":"McFadden","sequence":"additional","affiliation":[{"name":"Carolina Veterinary Specialists , Charlotte, NC"},{"name":"Carolina Veterinary Specialists , Matthews, 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