{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:16:49Z","timestamp":1791281809723,"version":"4.1.0"},"reference-count":45,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2013,7,1]],"date-time":"2013-07-01T00:00:00Z","timestamp":1372636800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Real-time 3-dimensional (RT3D) echocardiography provides a novel technique for assessing left atrial ejection fraction (LAEF) in dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Left atrial ejection fraction is associated with severity of myxomatous mitral valve disease (MMVD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Privately owned dogs; 101 with MMVD and 52 healthy control dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective observational study using RT3D echocardiographic estimations of LA volumes at atrial end-diastole and atrial end-systole to calculate LAEF in comparison with conventional 2-dimensional echocardiographic variables.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Left atrial ejection fraction decreased with increasing LA to aortic ratio (LA\/Ao), percentage increase in left ventricular (LV) internal dimension, corrected for body weight (BW), in diastole (LVIDd inc%) and systole (LVIDs inc%), and age for MMVD dogs, and with BW for control dogs. The final models in the multiple regression analyses included LVIDd inc% and age for MMVD dogs, and BW alone for control dogs. LAEF varied widely in both MMVD dogs and control dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and clinical importance<\/jats:title>\n                    <jats:p>The wide variation of LAEF and the fact that LAEF does not appear to be an independent marker of disease severity suggest that the clinical importance of determining LAEF in dogs with MMVD might be limited.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12113","type":"journal-article","created":{"date-parts":[[2013,6,3]],"date-time":"2013-06-03T12:59:40Z","timestamp":1370264380000},"page":"884-889","source":"Crossref","is-referenced-by-count":25,"title":["Left Atrial Ejection Fraction Assessed by Real-Time 3-Dimensional Echocardiography in Normal Dogs and Dogs with Myxomatous Mitral Valve Disease"],"prefix":"10.1093","volume":"27","author":[{"given":"A.","family":"Tidholm","sequence":"first","affiliation":[{"name":"Albano Animal Hospital , Danderyd,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"H\u00f6glund","sequence":"additional","affiliation":[{"name":"Physiology and Biochemistry, Swedish University of Agricultural Sciences Department of Anatomy, , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"H\u00e4ggstr\u00f6m","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences Department of Clinical Sciences, , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bodeg\u00e5rd-Westling","sequence":"additional","affiliation":[{"name":"Albano Animal Hospital , Danderyd,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ljungvall","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Swedish University of Agricultural Sciences Department of Clinical Sciences, , Uppsala,","place":["Sweden"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,7,1]]},"reference":[{"key":"2026020304271534700_jvim12113-bib-0001","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1136\/heart.85.3.272","article-title":"Effects of aging on left atrial reservoir, conduit, and booster pump function: A multi-institution acoustic quantification study","volume":"85","author":"Spencer","year":"2001","journal-title":"Heart"},{"key":"2026020304271534700_jvim12113-bib-0002","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1111\/j.1939-1676.2007.0008.x","article-title":"Survival characteristics and prognostic variables of dogs with mitral regurgitation attributable to myxomatous valve disease","volume":"22","author":"Borgarelli","year":"2008","journal-title":"J Vet Intern Med"},{"key":"2026020304271534700_jvim12113-bib-0003","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1291\/hypres.31.395","article-title":"Enhanced left atrial reservoir, increased conduit, and weakened booster pump function in hypertensive patients with paroxysmal atrial fibrillation","volume":"31","author":"Cui","year":"2008","journal-title":"Hypertens Res"},{"key":"2026020304271534700_jvim12113-bib-0004","first-page":"87","article-title":"Left atrial function: Bridge to central and hormonal determinants of exercise capacity in patients with chronic heart failure","volume":"58","author":"Ceresa","year":"2002","journal-title":"Monaldi Arch Chest Dis"},{"key":"2026020304271534700_jvim12113-bib-0005","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/S0002-9149(02)02864-3","article-title":"Left atrial volume as a morphophysiologic expression of left ventricular diastolic dysfunction and relation to cardiovascular risk burden","volume":"90","author":"Tsang","year":"2002","journal-title":"Am J Cardiol"},{"key":"2026020304271534700_jvim12113-bib-0006","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/S0735-1097(02)02305-7","article-title":"Determinants and prognostic value of left atrial volume in patients with dilated cardiomyopathy","volume":"40","author":"Rossi","year":"2002","journal-title":"J Am Coll Cardiol"},{"key":"2026020304271534700_jvim12113-bib-0007","doi-asserted-by":"crossref","first-page":"1972","DOI":"10.1016\/0735-1097(93)90787-2","article-title":"Estimation of left ventricular filling pressures using two-dimensional and Doppler echocardiography in adult patients with cardiac disease. 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