{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T23:21:15Z","timestamp":1772839275191,"version":"3.50.1"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Strategic Grant of the NSERC"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The neonatal period is associated with high morbidity and mortality in cloned calves.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To describe morbidity and mortality in cloned calves from birth to 2 years of age.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty-one somatic cell-derived Holstein calves delivered at a veterinary teaching hospital.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Medical files were retrospectively analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Four calves were stillborn. Five calves born alive had physical congenital defects. Twenty-three calves had an enlarged umbilical cord. Laboratory abnormalities included acidemia, respiratory acidosis, hyperlactatemia, anemia, stress leukogram, decreased total protein, albumin and globulins, and increased creatinine. Twenty-five calves survived the 1st hour of life. Among them, 11 stood without assistance within 6 hours of birth, 10 calves took longer than 6 hours to stand, and 4 never stood. Twenty-two calves suffered from anorexia. Twelve calves had complications arising from umbilical cord infections. Three calves developed idiopathic hyperthermia (&amp;gt;40\u00b0C). Eight calves suffered from gastrointestinal problems, including ruminal distension, abomasal ulcers, neonatal enteritis, intussusception, and abomasal displacement. Mortality between birth and 3 weeks of age was 32% (10\/31). Causes of death and reasons for euthanasia included stillbirths, respiratory failure, and limb deformities. Mortality between 3 weeks and 2 years of age was 19% (4\/21), with deaths in this group attributed to generalized peritonitis and complications arising from umbilical infections. Overall, mortality rate within 2 years of age was 14\/31 (45%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Respiratory problems, limb deformities, and umbilical infections were the most common causes of morbidity and mortality in these cloned calves.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12129","type":"journal-article","created":{"date-parts":[[2013,6,19]],"date-time":"2013-06-19T14:12:51Z","timestamp":1371651171000},"page":"1218-1227","source":"Crossref","is-referenced-by-count":16,"title":["Neonatal Morbidity and Mortality of 31 Calves Derived from Somatic Cloning"],"prefix":"10.1093","volume":"27","author":[{"given":"A.-C.","family":"Brisville","sequence":"first","affiliation":[{"name":"Veterinary Hospital Coeur-de-Lotbini\u00e8re , Laurier-Station, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Fecteau","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Montreal , Saint-Hyacinthe, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Boysen","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Calgary , Calgary, AB,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Desrochers","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, University of Montreal , Saint-Hyacinthe, QC,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Dorval","sequence":"additional","affiliation":[{"name":"Veterinary Hospital Rive-Sud , Brossard, 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