{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:56:53Z","timestamp":1791313013860,"version":"4.3.1"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2013,9,1]],"date-time":"2013-09-01T00:00:00Z","timestamp":1377993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100015900","name":"Ontario Veterinary College Pet Trust Fund","doi-asserted-by":"crossref","id":[{"id":"10.13039\/100015900","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dogs with hyperadrenocorticism are at risk of thromboembolic disease, which might be caused by an underlying hypercoagulable state.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To assess hemostatic function in dogs with ACTH-dependent hyperadrenocorticism (ADHAC) before and after treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Nineteen dogs with ADHAC and 40 normal dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, observational study. Dogs with ADHAC were recruited from the referral hospital patient population; normal dogs were recruited from staff and students at the study's institution. Hemostasis was assessed before and at 3 and 6 months after treatment with trilostane (T0, T3, T6) by kaolin-activated thrombelastography with platelet mapping (TEG-PM), prothrombin time, activated partial thromboplastin time, fibrinogen concentration, and antithrombin activity (AT).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dogs with ADHAC had statistically significantly increased \u03b1-angle (P &amp;lt; .01) and maximum amplitude (MA)thrombin (P &amp;lt; .01) on TEG-PM, and significantly decreased \u03ba (P &amp;lt; .005) at T0, T3, and T6. Platelet count (P &amp;lt; .001) and fibrinogen concentration (P &amp;lt; .001), but not AT activity, were increased in dogs with ADHAC at T0, T3, and T6.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Dogs with ADHAC have thrombelastographic evidence of hypercoagulability and remained hypercoagulable during treatment. AT deficiency does not appear to be involved in the pathogenesis of hypercoagulability in this population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12162","type":"journal-article","created":{"date-parts":[[2013,8,26]],"date-time":"2013-08-26T12:55:01Z","timestamp":1377521701000},"page":"1136-1142","source":"Crossref","is-referenced-by-count":43,"title":["Hypercoagulability and ACTH-Dependent Hyperadrenocorticism in Dogs"],"prefix":"10.1093","volume":"27","author":[{"given":"F.M.","family":"Park","sequence":"first","affiliation":[{"name":"Ontario Veterinary College, University of Guelph Department of Clinical Studies, , Guelph, ON"},{"name":"Animal Referral Hospital , Homebush, NSW"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.L.","family":"Blois","sequence":"additional","affiliation":[{"name":"Ontario Veterinary College, University of Guelph Department of Clinical Studies, , Guelph, 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