{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:32:37Z","timestamp":1791639157189,"version":"4.3.4"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary hyperaldosteronism (PHA) in cats occurs as a consequence of excessive hormone production by an adrenocortical tumor. Median survival time, association between tumor type and prognosis, and the likelihood that cats require continued medical therapy after surgery have not been systematically evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To determine the median survival time of cats with PHA treated by unilateral adrenalectomy. To examine if tumor type, anesthesia time, or tumor location (left or right side) affect survival and if affected cats require continued postoperative treatment for persistent hypertension or hypokalemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ten client-owned cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective study. Cats were diagnosed with PHA based on clinical signs, increased plasma aldosterone concentration, and advanced imaging. Cats underwent unilateral adrenalectomy. Survival time (days alive after surgery) was determined for each cat. Factors affecting median survival time were investigated, including histopathology, anesthesia time, and location (side) of the tumor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Eight of 10 cats survived to discharge from the hospital post adrenalectomy. Overall median survival was 1,297 days (range 2\u20131,582 days). The only significant factor affecting median survival time was anesthesia time &amp;gt;4 hours. Tumor type and location (side) did not significantly affect median survival time. No cats required continued medical treatment for PHA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Although PHA in cats is still considered an uncommon condition, it should be considered in middle to older aged cats with hypokalemic polymyopathy and systemic hypertension. Surgical correction by unilateral adrenalectomy is a viable approach to definitive treatment of PHA with no need for continued medical management.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12186","type":"journal-article","created":{"date-parts":[[2013,12,26]],"date-time":"2013-12-26T10:07:39Z","timestamp":1388052459000},"page":"137-143","source":"Crossref","is-referenced-by-count":40,"title":["Treatment of Aldosterone-Secreting Adrenocortical Tumors in Cats by Unilateral Adrenalectomy: 10 Cases (2002\u20132012)"],"prefix":"10.1093","volume":"28","author":[{"given":"A.J.","family":"Lo","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Studies, , Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.E.","family":"Holt","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Studies, , Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.C.","family":"Brown","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Studies, , Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.D.","family":"Schlicksup","sequence":"additional","affiliation":[{"name":"Veterinary Specialty Care , North Charleston, SC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.J.","family":"Orsher","sequence":"additional","affiliation":[{"name":"Veterinary Specialty and Emergency Center , Levittown, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.A.","family":"Agnello","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Pennsylvania Department of Clinical Studies, , Philadelphia, PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"2026020304345823700_jvim12186-bib-0001","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/B978-1-4377-2362-5.00025-6","volume-title":"Withrow and McEwen's Small Animal Clinical Oncology","author":"Lunn","year":"2013","edition":"5th ed"},{"key":"2026020304345823700_jvim12186-bib-0002","first-page":"3","article-title":"Primary aldosteronism, a new clinical syndrome","volume":"45","author":"Conn","year":"1955","journal-title":"J Lab Clin Med"},{"key":"2026020304345823700_jvim12186-bib-0003","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cvsm.2004.09.002","article-title":"Feline endocrinopathies","volume":"35","author":"Gunn-Moore","year":"2005","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026020304345823700_jvim12186-bib-0004","first-page":"153","article-title":"Hyperaldosteronism in cats","volume":"9","author":"Ahn","year":"1994","journal-title":"Semin Vet Med Surg (Small Anim)"},{"key":"2026020304345823700_jvim12186-bib-0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1053\/j.ctsap.2007.02.004","article-title":"Feline adrenal disorders","volume":"22","author":"Chiaramonte","year":"2007","journal-title":"Clin Tech Small Anim Pract"},{"key":"2026020304345823700_jvim12186-bib-0006","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.jfms.2011.07.017","article-title":"Primary hyperaldosteronism: Expanding the diagnostic net","volume":"13","author":"Djajadiningrat-Laanen","year":"2011","journal-title":"J Feline Med Surg"},{"key":"2026020304345823700_jvim12186-bib-0007","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.suc.2009.06.017","article-title":"Aldosteronomas\u2013state of the art","volume":"89","author":"McKenzie","year":"2009","journal-title":"Surg Clin North Am"},{"key":"2026020304345823700_jvim12186-bib-0008","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/j.1748-5827.1983.tb00370.x","article-title":"Primary aldosteronism (Conn's syndrome) in a cat; 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