{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:32:40Z","timestamp":1791639160308,"version":"4.3.4"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2013,11,1]],"date-time":"2013-11-01T00:00:00Z","timestamp":1383264000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100008037","name":"Netherlands Association for Companion Animal Medicine of the Royal Netherlands Veterinary Association","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008037","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Stichting Diergeneeskundig Onderzoek Gezelschapsdieren"},{"name":"Rein Vet Products"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Primary hyperaldosteronism (PHA) in cats is suggested by clinical signs and an elevated plasma aldosterone-to-renin ratio (ARR), but a test to confirm the diagnosis is lacking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Fludrocortisone does not suppress urinary aldosterone excretion in cats with PHA, but does so in cats with arterial hypertension because of other causes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Nineteen client-owned cats with arterial hypertension because of PHA (n = 9) or other causes (n = 10).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective clinical study. The urinary aldosterone-to-creatinine ratio (UACR) was determined in morning urine before, during, and after 4 days of oral fludrocortisone administration in a dose of 0.05 mg\/kg q12h. Arterial blood pressure and plasma potassium concentration were measured before and after fludrocortisone administration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A basal UACR above 46.5 \u00d7 10\u22129, the upper limit of the reference range, was found in 3 cats with PHA. All PHA cats had basal UACRs &amp;gt;7.5 \u00d7 10\u22129. In all non-PHA cats with a basal UACR &amp;gt;7.5 \u00d7 10\u22129, fludrocortisone administration induced &amp;gt;50% suppression. In contrast, fludrocortisone administration resulted in &amp;lt;50% suppression in 6 of the 9 PHA cats. Neither basal UACR, nor UACR after suppression testing, correlated with the etiology of PHA (adenoma, adenocarcinoma, or suspected bilateral hyperplasia of the zona glomerulosa). Fludrocortisone induced hypokalemia in 7 cats, but did not induce or exacerbate arterial hypertension.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Measuring the UACR before and after 4 days of administering fludrocortisone is a practical method of confirming most cases of PHA in cats, and of substantiating the absence of PHA in cats having an ARR within the reference range.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12216","type":"journal-article","created":{"date-parts":[[2013,10,15]],"date-time":"2013-10-15T12:09:39Z","timestamp":1381838979000},"page":"1493-1499","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of the Oral Fludrocortisone Suppression Test for Diagnosing Primary Hyperaldosteronism in Cats"],"prefix":"10.1093","volume":"27","author":[{"given":"S.C.","family":"Djajadiningrat-Laanen","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Utrecht University Department of Clinical Sciences of Companion Animals, , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Galac","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Utrecht University Department of Clinical Sciences of Companion Animals, , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.H.","family":"Boev\u00e9","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine, Utrecht University Department of Clinical Sciences of Companion Animals, , Utrecht,","place":["The Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.A.E.B.","family":"Boroffka","sequence":"additional","affiliation":[{"name":"Faculty 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