{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T02:51:23Z","timestamp":1774579883478,"version":"3.50.1"},"reference-count":7,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2014,1,1]],"date-time":"2014-01-01T00:00:00Z","timestamp":1388534400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,1,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Despite the popularity of canine blood donor (BD) programs, there is scarce scientific information regarding iron status in this canine population of dogs.<\/jats:p>\n <\/jats:sec>\n \n Objective<\/jats:title>\n To assess iron status in dogs used in a blood donor program.<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n A total of 130 healthy dogs (75 BD, 55 controls [C]) were included. A subset of dogs (n = 12) were used to evaluate the effects of repetitive donations by having a second and more recent sample analyzed.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Serum iron concentration (SI), unsaturated iron-binding capacity (UIBC), total iron-binding capacity (TIBC), and percentage transferrin saturation (%SAT) were obtained. Values were compared using a 2-way ANOVA (factors: BD status, breed). For the subset of BD, the first sample (less frequent donors -LD-, after a mean of 3.8 donations) was compared to a second sample (experienced donors -ED-, mean 13.6 donations) using a paired t-test.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n SI (183.7 \u00b1 55.3 \u03bcg\/dL) and %SAT (55.7 \u00b1 17.4%) were higher and UIBC (152.6 \u00b1 73.3 \u03bcg\/dL) was lower in BD dogs than in C (153.9 \u00b1 51.7 \u03bcg\/dL, 43.8 \u00b1 17.8%, and 224.1 \u00b1 120.6 \u03bcg\/dL, respectively). Also, UIBC and TIBC were lower, and %SAT higher in Greyhounds when compared with non-Greyhounds. ED had decreased %SAT and increased UIBC and TIBC when compared with LD.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Importance<\/jats:title>\n Our canine BD population did not have iron deficiency and had higher SI concentration than C. However, ED (~14 consecutive blood donations every ~8 weeks) developed a mild iron deficiency, although values were still within canine reference intervals. Greyhounds have higher %SAT than non-Greyhounds, which might be a breed-specific peculiarity.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jvim.12254","type":"journal-article","created":{"date-parts":[[2013,11,25]],"date-time":"2013-11-25T17:12:18Z","timestamp":1385399538000},"page":"211-214","source":"Crossref","is-referenced-by-count":9,"title":["Iron Status in Blood Donor Dogs"],"prefix":"10.1093","volume":"28","author":[{"given":"S.","family":"Zald\u00edvar-L\u00f3pez","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Clinical Sciences, , Columbus, OH"},{"name":"The Research Institute at Nationwide Children's Hospital , Columbus, OH"},{"name":"Facultad de Veterinaria, Universidad de C\u00f3rdoba Grupo de Gen\u00f3mica y Mejora Animal, Departmento de Gen\u00e9tica, , C\u00f3rdoba,","place":["Spain"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.C.","family":"Iazbik","sequence":"additional","affiliation":[{"name":"Veterinary Medical Center, The Ohio State University , Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.M.","family":"Mar\u00edn","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Clinical Sciences, , Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.G.","family":"Couto","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine Department of Veterinary Clinical Sciences, , Columbus, OH"},{"name":"Veterinary Medical Center, The Ohio State University , Columbus, OH"},{"name":"Comprehensive Cancer Center, The Ohio State University , Columbus, OH"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,1,1]]},"reference":[{"key":"2026020304342230100_jvim12254-bib-0001","first-page":"116","volume-title":"Hematology: Clinical Principles and Applications","author":"Coleman","year":"2007","edition":"3rd ed"},{"key":"2026020304342230100_jvim12254-bib-0002","doi-asserted-by":"crossref","first-page":"151","DOI":"10.5326\/JAAHA-MS-5553","article-title":"Iron homeostasis and disorders in dogs and cats: A review","volume":"47","author":"McCown","year":"2011","journal-title":"J Am Anim Hosp Assoc"},{"key":"2026020304342230100_jvim12254-bib-0003","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1111\/j.1537-2995.2011.03401.x","article-title":"Iron deficiency in blood donors: The REDS-II Donor Iron Status Evaluation (RISE) study","volume":"52","author":"Cable","year":"2012","journal-title":"Transfusion"},{"key":"2026020304342230100_jvim12254-bib-0004","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1939-165X.2005.tb00004.x","article-title":"Hematologic and biochemical abnormalities indicating iron deficiency are associated with decreased reticulocyte hemoglobin content (CHr) and reticulocyte volume (rMCV) in dogs","volume":"34","author":"Steinberg","year":"2005","journal-title":"Vet Clin Pathol"},{"key":"2026020304342230100_jvim12254-bib-0005","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1111\/j.1537-2995.2008.01823.x","article-title":"Behavioral, biochemical, and genetic analysis of iron metabolism in high-intensity blood donors","volume":"48","author":"Mast","year":"2008","journal-title":"Transfusion"},{"key":"2026020304342230100_jvim12254-bib-0006","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1939-165X.2010.00261.x","article-title":"Prevalence of dog erythrocyte antigens in retired racing Greyhounds","volume":"39","author":"Iazbik","year":"2010","journal-title":"Vet Clin Pathol"},{"key":"2026020304342230100_jvim12254-bib-0007","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/vcp.12066","article-title":"Markers of iron metabolism in retired racing Greyhounds with and without osteosarcoma","volume":"42","author":"Caro","year":"2013","journal-title":"Vet Clin Pathol"}],"container-title":["Journal of Veterinary Internal 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