{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:07:24Z","timestamp":1788869244940,"version":"build-2803163510"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100007015","name":"University of Wisconsin-Madison","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"publisher"}]},{"name":"School of Veterinary Medicine, Companion Animal Grant"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Long-duration beta-lactam antibiotics are used for empirical treatment in female dogs with uncomplicated bacterial cystitis. However, women with bacterial cystitis are treated with short-duration potentiated sulfonamides because longer courses of beta-lactams result in lower cure and higher recurrence rates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Short-duration potentiated sulfonamide treatment is more efficacious than long-duration beta-lactam treatment in achieving clinical and microbiological cures in female dogs with uncomplicated bacterial cystitis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Thirty-eight client-owned female dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized, double-blinded, placebo-controlled clinical trial. Dogs were treated with TMP-SMX (15 mg\/kg PO q12h for 3 days followed by a placebo capsule PO q12h for 7 days; Group SDS; n = 20) or cephalexin (20 mg\/kg PO q12h for 10 days; Group LDBL; n = 18). Dogs were monitored for clinical and microbiological cure during treatment and at short- and long-term follow-up.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>No statistically significant differences were found between treatment groups in clinical cure rates after 3 days of treatment (89% SDS, 94% LDBL; P = 1.00) and 4 days (85% SDS, 72% LDBL; P = .44) or &amp;gt;30 days (50% SDS, 65% LDBL; P = .50) after conclusion of treatment or in microbiological cure rates 4 days (59% SDS, 36% LDBL; P = .44) or &amp;gt;30 days (44% SDS, 20% LDBL; P = .40) after conclusion of treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>We did not identify a difference in cure rates between short-duration sulfonamide and long-duration beta-lactam treatments in female dogs with uncomplicated cystitis. Long-term cure rates in both treatment groups were low. In some female dogs, \u201cuncomplicated\u201d bacterial cystitis may be more complicated than previously recognized.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12324","type":"journal-article","created":{"date-parts":[[2014,3,27]],"date-time":"2014-03-27T14:27:24Z","timestamp":1395930444000},"page":"818-826","source":"Crossref","is-referenced-by-count":48,"title":["Short- and Long-Term Cure Rates of Short-Duration Trimethoprim-Sulfamethoxazole Treatment in Female Dogs with Uncomplicated Bacterial Cystitis"],"prefix":"10.1093","volume":"28","author":[{"given":"S.","family":"Clare","sequence":"first","affiliation":[{"name":"School of Veterinary Medicine, University of Wisconsin Department of Medical Sciences, , Madison, WI"},{"name":"Veterinary Referral and Critical Care , Richmond, VA(Clare)"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.A.","family":"Hartmann","sequence":"additional","affiliation":[{"name":"Veterinary Medical Teaching Hospital, School of Veterinary Medicine, University of Wisconsin , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jooss","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Wisconsin Department of Medical Sciences, , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Bachar","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Wisconsin Department of Medical Sciences, , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y.Y.","family":"Wong","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Wisconsin Department of Medical Sciences, , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.A.","family":"Trepanier","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Wisconsin Department of Medical Sciences, , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.R.","family":"Viviano","sequence":"additional","affiliation":[{"name":"School of Veterinary Medicine, University of Wisconsin Department of Medical Sciences, , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"2026020304381114200_jvim12324-bib-0001","volume-title":"Diagnosing Initial and Recurrent Urinary Tract Infections in Dogs","author":"Chew","year":"2001"},{"key":"2026020304381114200_jvim12324-bib-0002","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.pop.2008.01.001","article-title":"Urinary tract infections","volume":"35","author":"Drekonja","year":"2008","journal-title":"Prim Care"},{"key":"2026020304381114200_jvim12324-bib-0003","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1056\/NEJM197802232980802","article-title":"Efficacy of single-dose and conventional amoxicillin therapy in urinary-tract infection localized by the antibody-coated bacteria technique","volume":"298","author":"Fang","year":"1978","journal-title":"N Engl J Med"},{"key":"2026020304381114200_jvim12324-bib-0004","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1067\/mda.2003.11","article-title":"Urinary tract infection: Traditional pharmacologic therapies","volume":"49","author":"Nicolle","year":"2003","journal-title":"Dis Mon"},{"key":"2026020304381114200_jvim12324-bib-0005","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1111\/j.1365-2672.2008.04115.x","article-title":"Antibiotherapy and pathogenesis of uncomplicated UTI: Difficult relationships","volume":"106","author":"Moura","year":"2009","journal-title":"J Appl Microbiol"},{"key":"2026020304381114200_jvim12324-bib-0006","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1001\/jama.1995.03520250057034","article-title":"Randomized comparative trial and cost analysis of 3-day antimicrobial regimens for treatment of acute cystitis in women","volume":"273","author":"Hooton","year":"1995","journal-title":"JAMA"},{"key":"2026020304381114200_jvim12324-bib-0007","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0002-9343(99)00026-1","article-title":"A randomized trial of short-course ciprofloxacin, ofloxacin, or trimethoprim\/sulfamethoxazole for the treatment of acute urinary tract infection in women. 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