{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T15:29:13Z","timestamp":1781191753301,"version":"3.54.1"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2014,5,1]],"date-time":"2014-05-01T00:00:00Z","timestamp":1398902400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Immune-mediated polyarthopathy (IMPA) is common in dogs, and is monitored by serial arthrocenteses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Plasma C-reactive protein (CRP), interleukin-6 (IL-6), and CXCL8 (interleukin-8) would serve as noninvasive markers of joint inflammation in IMPA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Nine client-owned dogs with idiopathic IMPA; 6 healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective study. Plasma CRP, IL-6, and CXCL8 were measured by ELISA at baseline, 2, and 4 weeks during treatment with prednisone at 50 mg\/m2\/day. Arthrocenteses, the canine brief pain inventory (CBPI), and accelerometry collars were used to assess joint inflammation, lameness, and mobility at all 3 time points.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>C-reactive protein concentrations were higher in IMPA dogs (median 91.1 \u03bcg\/mL, range 76.7\u2013195.0) compared with controls (median &amp;lt;6.3 \u03bcg\/mL, &amp;lt;6.3\u201313.7; P = .0035), and were significantly lower at week 2 (10.6 \u03bcg\/mL, &amp;lt;6.3\u201348.8) and week 4 (&amp;lt;6.3 \u03bcg\/mL, &amp;lt;6.3\u201324.4; P &amp;lt; .001).<\/jats:p>\n                    <jats:p>C-reactive protein was correlated with median CBPI scores (r = 0.68; P = .0004), joint cellularity (r = 0.49, P = .011), and mobility by accelerometry (r = \u22120.42, P = .048). Plasma IL-6 concentrations were also higher in IMPA dogs (median 45.9 pg\/mL), compared with controls (median &amp;lt;15.7 pg\/mL; P = .0008). IL-6 was lower in IMPA dogs by week 4 (&amp;lt;15.7 pg\/mL; P = .0099), and was modestly correlated with CBPI scores (r = 0.47, P = .023). CXCL8 did not differ significantly between IMPA and healthy dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma CRP and IL-6 might be useful surrogate markers of synovial inflammation and disease activity in dogs with IMPA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12351","type":"journal-article","created":{"date-parts":[[2014,4,3]],"date-time":"2014-04-03T14:51:11Z","timestamp":1396536671000},"page":"905-911","source":"Crossref","is-referenced-by-count":44,"title":["Serum Biomarkers of Clinical and Cytologic Response in Dogs with Idiopathic Immune-Mediated Polyarthropathy"],"prefix":"10.1093","volume":"28","author":[{"given":"J.D.","family":"Foster","sequence":"first","affiliation":[{"name":"University of Wisconsin-Madison Department of Medical Sciences, , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Sample","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison Department of Surgical Sciences, , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Kohler","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison Department of Medical Sciences, , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Watson","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison Department of Medical Sciences, , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Muir","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison Department of Surgical Sciences, , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.A.","family":"Trepanier","sequence":"additional","affiliation":[{"name":"University of Wisconsin-Madison Department of Medical Sciences, , Madison, WI"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,5,1]]},"reference":[{"key":"2026020304383748600_jvim12351-bib-0001","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1111\/j.1748-5827.1998.tb03711.x","article-title":"Diagnostic investigations in 101 dogs with pyrexia of unknown origin","volume":"39","author":"Dunn","year":"1998","journal-title":"J Small Anim Pract"},{"key":"2026020304383748600_jvim12351-bib-0002","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1111\/j.1939-1676.2005.tb02743.x","article-title":"Suppurative, nonseptic polyarthropathy in dogs","volume":"19","author":"Rondeau","year":"2005","journal-title":"J Vet Intern Med"},{"key":"2026020304383748600_jvim12351-bib-0003","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1111\/j.1748-5827.1987.tb01316.x","article-title":"Immune-based non-erosive inflammatory joint disease of the dog. 3. 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