{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T10:16:51Z","timestamp":1791281811428,"version":"4.1.0"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n Left atrial size is prognostically important in dogs with myxomatous mitral valve disease (MMVD).<\/jats:p>\n <\/jats:sec>\n \n Hypothesis\/Objectives<\/jats:title>\n To compare the level of agreement in identification of left atrial enlargement (LAE) between the left atrial-to-aortic root ratio (LA : Ao) and left atrial volume using the biplane area-length method indexed to body weight (LA Vol\/BW).<\/jats:p>\n <\/jats:sec>\n \n Animals<\/jats:title>\n Sixty dogs with MMVD and 22 normal dogs were prospectively studied with 2-dimensional echocardiography.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n The upper limit of normal for LA Vol\/BW was defined as 1.1 mL\/kg. LA : Ao was deemed normal if \u22641.5. To define overall disease severity, each dog was assigned a mitral regurgitation severity score (MRSS) based on echocardiographic parameters that did not include left atrial size. ACVIM staging also was utilized.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Of 60 affected dogs, 20 were ACVIM Stage B1, 25 were Stage B2, and 15 were Stage C. LA Vol\/BW identified LAE in 12 cases in which LA : Ao was normal; 7 of these were Stage B1 and 5 were Stage B2. This diagnostic disagreement was significant (P = .00012). Of the 12 cases in which diagnostic discrepancies were identified, 5\/5 of the B2 dogs and 3\/7 B1 dogs had a moderate MRSS, whereas 4\/7 B1 dogs had a mild MRSS. No diagnostic discrepancies between LA : Ao and LA Vol\/BW were apparent in dogs with a severe MRSS.<\/jats:p>\n <\/jats:sec>\n \n Conclusions and Clinical Importance<\/jats:title>\n This study shows evidence of diagnostic disagreement between LA : Ao and LA Vol\/BW for assessment of LAE. LA Vol\/BW may be superior to LA : Ao for identification of mild LAE.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jvim.12410","type":"journal-article","created":{"date-parts":[[2014,7,23]],"date-time":"2014-07-23T10:19:47Z","timestamp":1406110787000},"page":"1527-1533","source":"Crossref","is-referenced-by-count":68,"title":["Discrepancies in Identification of Left Atrial Enlargement Using Left Atrial Volume versus Left Atrial-to-Aortic Root Ratio in Dogs"],"prefix":"10.1093","volume":"28","author":[{"given":"S.","family":"Wesselowski","sequence":"first","affiliation":[{"name":"Virginia-Maryland Regional College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Borgarelli","sequence":"additional","affiliation":[{"name":"Virginia-Maryland Regional College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Blacksburg, 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