{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T06:15:14Z","timestamp":1776579314504,"version":"3.51.2"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Vomiting is a common complication associated with the use of hydromorphine for pre-emptive analgesia in dogs. The ideal anti-emetic protocol for prevention of this complication has not been established.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Maropitant administered concurrently or before hydromorphone would reduce the incidence of vomiting, signs of nausea, ptyalism, and increased panting compared to administration of acepromazine or a 0.9% saline control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty mixed-breed female dogs scheduled for ovariohysterectomy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Randomized, blinded, placebo-controlled experimental study. Dogs were assigned to 4 experimental groups with 15 dogs per group. All groups received 0.2 mg\/kg of hydromorphone IM. Group \u201cControl\u201d received 0.1 mL\/kg saline SC 30\u201345 minutes before hydromorphone, group \u201cMarop1\u201d received 1 mg\/kg maropitant SC 30\u201345 minutes before hydromorphone, group \u201cAce\u201d received 0.02 mg\/kg IM acepromazine 30\u201345 minutes before hydromorphone, and group \u201cMarop2\u201d received 1 mg\/kg SC maropitant concurrently with hydromorphone. A trained and blinded observer documented adverse events from the time hydromorphone was administered until the time dogs were induced for surgery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Marop1 had significantly less vomiting (0%) compared to Control (87%; P &amp;lt; .01) and Ace (53%; P &amp;lt; .01). Marop2 had significantly less vomiting (27%) compared to Control (P &amp;lt; .01). Marop1 had significantly greater incidence of ptyalism (73%) compared to Ace (P &amp;lt; .01; 20%). Ace showed significantly less panting (33%) compared to Marop2 (93%; P &amp;lt; .01).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>In healthy dogs, maropitant citrate administered before hydromorphone significantly decreases the incidence of vomiting in dogs but does not improve signs of nausea, ptyalism, or increased panting.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12414","type":"journal-article","created":{"date-parts":[[2014,8,21]],"date-time":"2014-08-21T14:23:09Z","timestamp":1408630989000},"page":"1414-1417","source":"Crossref","is-referenced-by-count":29,"title":["Effects of Maropitant Citrate or Acepromazine on the Incidence of Adverse Events Associated with Hydromorphone Premedication in Dogs"],"prefix":"10.1093","volume":"28","author":[{"given":"A.K.","family":"Claude","sequence":"first","affiliation":[{"name":"Mississippi State College of Veterinary Medicine, Mississippi State University , Starkville, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Dedeaux","sequence":"additional","affiliation":[{"name":"Louisiana State College of Veterinary Medicine, Louisiana State University , Baton Rouge, LA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Chiavaccini","sequence":"additional","affiliation":[{"name":"Mississippi State College of Veterinary Medicine, Mississippi State University , Starkville, MS"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Hinz","sequence":"additional","affiliation":[{"name":"Mississippi State College of Veterinary Medicine, Mississippi State University , Starkville, 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