{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:30:35Z","timestamp":1791639035639,"version":"4.3.4"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2014,9,1]],"date-time":"2014-09-01T00:00:00Z","timestamp":1409529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Measurement of plasma renin activity (PRA) is the gold standard for monitoring mineralocorticoid treatment in humans with primary hypoadrenocorticism (PH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To compare PRA in dogs with newly diagnosed PH, dogs with diseases mimicking PH, and healthy dogs, and evaluate measurement of PRA to monitor therapeutic effects in dogs with PH treated with different mineralocorticoids.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Eleven dogs with newly diagnosed PH (group 1), 10 dogs with diseases mimicking PH (group 2), 21 healthy dogs (group 3), 17 dogs with treated PH (group 4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In group 1, PRA was measured before treatment and at different times after initiating treatment. In groups 2 and 3, PRA was measured at initial presentation only. In group 4, no baseline PRA was obtained but PRA was measured once or every 1\u20136 months during treatment. Mineralocorticoid treatment consisted of fludrocortisone acetate (FC) or desoxycorticosterone pivalate (DOCP).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Plasma renin activity before treatment was increased in dogs with PH compared to normal dogs and dogs with diseases mimicking PH with median activity of 27, 0.8, and 1.0 ng\/mL\/h, respectively. In dogs with PH, PRA decreased and normalized with mineralocorticoid treatment using DOCP but not with FC. In dogs treated with DOCP, PRA was lower than in dogs treated with FC. Plasma sodium concentrations were higher and potassium concentrations were lower with DOCP treatment compared to FC treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Plasma renin activity is a reliable tool for monitoring mineralocorticoid treatment. DOCP treatment more effectively suppresses PRA compared to FC in dogs with PH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12426","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T13:48:48Z","timestamp":1412171328000},"page":"1471-1478","source":"Crossref","is-referenced-by-count":29,"title":["Use of Plasma Renin Activity to Monitor Mineralocorticoid Treatment in Dogs with Primary Hypoadrenocorticism: Desoxycorticosterone Versus Fludrocortisone"],"prefix":"10.1093","volume":"28","author":[{"given":"M.E.","family":"Baumstark","sequence":"first","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Nussberger","sequence":"additional","affiliation":[{"name":"Division of Angiology and Hypertension , Department of Medicine, Lausanne University Hospital, Lausanne,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.S.","family":"Boretti","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.W.","family":"Baumstark","sequence":"additional","affiliation":[{"name":"University Medical Center , Freiburg,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Riond","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Reusch","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.S.","family":"Sieber-Ruckstuhl","sequence":"additional","affiliation":[{"name":"Clinic for Small Animal Internal Medicine, Vetsuisse Faculty, University of Zurich , Zurich,","place":["Switzerland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2014,9,1]]},"reference":[{"key":"2026020304403167900_jvim12426-bib-0001","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1939-1676.2006.tb02896.x","article-title":"Aldosterone-to-renin and cortisol-to-adrenocorticotropic hormone ratios in healthy dogs and dogs with primary hypoadrenocorticism","volume":"20","author":"Javadi","year":"2006","journal-title":"J Vet Intern Med"},{"key":"2026020304403167900_jvim12426-bib-0002","first-page":"63","article-title":"Canine hypoadrenocorticism: Part I","volume":"51","author":"Klein","year":"2010","journal-title":"Can Vet J Rev"},{"key":"2026020304403167900_jvim12426-bib-0003","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1939-1676.1997.tb00072.x","article-title":"Treatment and long-term follow-up of 205 dogs with hypoadrenocorticism","volume":"11","author":"Kintzer","year":"1997","journal-title":"J Vet Intern Med"},{"key":"2026020304403167900_jvim12426-bib-0004","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2460\/javma.1993.202.03.392","article-title":"Efficacy of microcrystalline desoxycorticosterone pivalate for treatment of hypoadrenocorticism in dogs. DOCP Clinical Study Group","volume":"202","author":"Lynn","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"2026020304403167900_jvim12426-bib-0005","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1111\/j.1748-5827.1996.tb02377.x","article-title":"Diagnosis and treatment of naturally occurring hypoadrenocorticism in 42 dogs","volume":"37","author":"Meli\u00e1n","year":"1996","journal-title":"J Small Anim Pract"},{"key":"2026020304403167900_jvim12426-bib-0006","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0007-1935(91)90091-Z","article-title":"Treatment of canine hypoadrenocorticism with microcrystalline desoxycorticosterone pivalate","volume":"147","author":"Lynn","year":"1991","journal-title":"Br Vet J"},{"key":"2026020304403167900_jvim12426-bib-0007","first-page":"1192","article-title":"Treatment of hypoadrenocorticism in dogs","volume":"202","author":"Pascoe","year":"1993","journal-title":"J Am Vet Med Assoc"},{"key":"2026020304403167900_jvim12426-bib-0008","first-page":"103","article-title":"Plasma renin activity in management of Addison's disease","volume":"36","author":"Linquette","year":"1975","journal-title":"Ann Endocrinol"},{"key":"2026020304403167900_jvim12426-bib-0009","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1007\/BF01469025","article-title":"Control of mineralocorticoid substitution in Addison's disease by plasma renin measurement","volume":"54","author":"Oelkers","year":"1976","journal-title":"Klin Wochenschr"},{"key":"2026020304403167900_jvim12426-bib-0010","first-page":"259","article-title":"Diagnosis and therapy surveillance in Addison's disease: Rapid adrenocorticotropin (ACTH) test and measurement of plasma ACTH, renin activity, and aldosterone","volume":"75","author":"Oelkers","year":"1992","journal-title":"J Clin Endocrinol Metab"},{"key":"2026020304403167900_jvim12426-bib-0011","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.ecl.2009.01.008","article-title":"Fine tuning for quality of life: 21st century approach to treatment of Addison's disease","volume":"38","author":"Reisch","year":"2009","journal-title":"Endocrinol Metab Clin North Am"},{"key":"2026020304403167900_jvim12426-bib-0012","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/jvim.12243","article-title":"Evaluation of aldosterone concentrations in dogs with hypoadrenocorticism","volume":"28","author":"Baumstark","year":"2014","journal-title":"J Vet Intern Med"},{"key":"2026020304403167900_jvim12426-bib-0013","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1097\/00005344-198701000-00007","article-title":"Repeated administration of the converting enzyme inhibitor cilazapril to normal volunteers","volume":"9","author":"Nussberger","year":"1987","journal-title":"J Cardiovasc Pharmacol"},{"key":"2026020304403167900_jvim12426-bib-0014","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1161\/01.HYP.16.5.564","article-title":"Determinants of angiotensin II generation during converting enzyme inhibition","volume":"16","author":"Juillerat","year":"1990","journal-title":"Hypertension"},{"key":"2026020304403167900_jvim12426-bib-0015","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1210\/jc.2009-0032","article-title":"The approach to the adult with newly diagnosed adrenal insufficiency","volume":"94","author":"Arlt","year":"2009","journal-title":"J Clin Endocrinol Metab"},{"key":"2026020304403167900_jvim12426-bib-0016","first-page":"112","article-title":"Mineralocorticoid therapy of spontaneous primary hypoadrenocorticism in 176 dogs","volume":"6","author":"Kintzer","year":"1992","journal-title":"J Vet Intern Med"},{"key":"2026020304403167900_jvim12426-bib-0017","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/avj.12019","article-title":"Lower initial dose desoxycorticosterone pivalate for treatment of canine primary hypoadrenocorticism","volume":"91","author":"Bates","year":"2013","journal-title":"Aust Vet J"},{"key":"2026020304403167900_jvim12426-bib-0018","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1159\/000327794","article-title":"Health problems in congenital adrenal hyperplasia due to 21-hydroxylase deficiency","volume":"76","author":"Reisch","year":"2011","journal-title":"Horm Res Paediatr"},{"key":"2026020304403167900_jvim12426-bib-0019","doi-asserted-by":"crossref","first-page":"327","DOI":"10.2460\/javma.1995.206.03.327","article-title":"Effects of desoxycorticosterone pivalate administration on blood pressure in dogs with primary hypoadrenocorticism","volume":"206","author":"Kaplan","year":"1995","journal-title":"J Am Vet Med Assoc"},{"key":"2026020304403167900_jvim12426-bib-0020","doi-asserted-by":"crossref","first-page":"1954","DOI":"10.2460\/ajvr.1993.54.11.1954","article-title":"Toxicity of desoxycorticosterone pivalate given at high dosages to clinically normal beagles for six months","volume":"54","author":"Chow","year":"1993","journal-title":"Am J Vet Res"},{"key":"2026020304403167900_jvim12426-bib-0021","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/j.avsg.2011.12.001","article-title":"Role of the renin-angiotensin system in the pathogeneis of intimal hyperplasia: Therapeutic potential for prevention of vein graft failure","volume":"26","author":"Osgood","year":"2012","journal-title":"Ann Vasc Surg"},{"key":"2026020304403167900_jvim12426-bib-0022","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1056\/NEJM197203022860901","article-title":"Essential hypertension: Renin and aldosterone, heart attack and stroke","volume":"286","author":"Brunner","year":"1972","journal-title":"N Engl J Med"},{"key":"2026020304403167900_jvim12426-bib-0023","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/0002-9343(73)90131-9","article-title":"Renin as a risk factor in essential hypertension: More evidence","volume":"55","author":"Brunner","year":"1973","journal-title":"Am J Med"},{"key":"2026020304403167900_jvim12426-bib-0024","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1056\/NEJM199104183241605","article-title":"Association of the renin-sodium profile with the risk of myocardial infarction in patients with hypertension","volume":"324","author":"Alderman","year":"1991","journal-title":"N Engl J Med"},{"key":"2026020304403167900_jvim12426-bib-0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0895-7061(96)00301-9","article-title":"Plasma renin activity: A risk factor for myocardial infarction in hypertensive patients","volume":"10","author":"Alderman","year":"1997","journal-title":"Am J Hypertens"},{"key":"2026020304403167900_jvim12426-bib-0026","first-page":"179","article-title":"Canine hypoadrenocorticism: Part II","volume":"51","author":"Klein","year":"2010","journal-title":"Can Vet J Rev"},{"key":"2026020304403167900_jvim12426-bib-0027","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1097\/00004872-200402000-00023","article-title":"Active renin versus plasma renin activity to define aldosterone-to-renin ratio for primary aldosteronism","volume":"22","author":"Ferrari","year":"2004","journal-title":"J Hypertens"},{"key":"2026020304403167900_jvim12426-bib-0028","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1373\/clinchem.2008.118000","article-title":"Activity assays and immunoassays for plasma Renin and prorenin: Information provided and precautions necessary for accurate measurement","volume":"55","author":"Campbell","year":"2009","journal-title":"Clin Chem"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvim.12426","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvim.12426","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/28\/5\/1471\/66686633\/jvim12426.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/28\/5\/1471\/66686633\/jvim12426.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:40:58Z","timestamp":1770111658000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/28\/5\/1471\/8452250"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,1]]},"references-count":28,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,9,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.12426","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2014,9]]},"published":{"date-parts":[[2014,9,1]]}}}