{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T18:17:42Z","timestamp":1770747462162,"version":"3.49.0"},"reference-count":30,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2014,11,1]],"date-time":"2014-11-01T00:00:00Z","timestamp":1414800000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2014,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>People with renal disease develop a dyslipidemia that contributes to progression of renal injury and development of cardiovascular disease. Lipoproteins in dogs with renal disease have not been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Dogs with chronic kidney disease (CKD) have dyslipidemia characterized by increased lower density lipoproteins and decreased high-density lipoproteins (HDLs). The degree of dyslipidemia is positively correlated with severity of disease, as reflected by serum creatinine concentration.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Prospective study of client-owned dogs presented to the Cornell University Hospital for Animals: 29 dogs with confirmed CKD, 5 dogs with nephrotic syndrome (NS), and 12 healthy control dogs presented for routine vaccinations, dental cleaning, or owned by students.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Lipoprotein electrophoresis was used to quantify relative proportions of the 3 main classes of lipoproteins in canine serum: low-density lipoproteins (LDL), very low-density lipoproteins (VLDL), and HDL. Serum cholesterol and creatinine concentrations; urinalysis and urine protein-to-creatinine ratio were measured by standard methods.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Dyslipidemia was consistently found in dogs with CKD and NS and was characterized by a decrease in HDL and variable increases in LDL and VLDL. Dogs with NS had a proportionately greater increase in the VLDL fraction, as compared with dogs with CKD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Dyslipidemia similar to that documented in people with renal disease occurs in dogs with CKD, despite serum cholesterol concentrations often being within the reference interval. The contribution of altered lipoproteins to the pathogenesis of renal disease in dogs warrants additional study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12450","type":"journal-article","created":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T11:37:27Z","timestamp":1412163447000},"page":"1692-1698","source":"Crossref","is-referenced-by-count":17,"title":["Serum Lipoprotein Changes in Dogs with Renal Disease"],"prefix":"10.1093","volume":"28","author":[{"given":"E.","family":"Behling-Kelly","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, Cornell University Department of Population Medicine and Diagnostic Sciences, , Ithaca, NY"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,11,1]]},"reference":[{"key":"2026020304405945600_jvim12450-bib-0001","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1007\/s10157-012-0655-x","article-title":"Clinical assessment and management of dyslipidemia in patients with chronic kidney disease","volume":"16","author":"Nitta","year":"2012","journal-title":"Clin Exp Nephrol"},{"key":"2026020304405945600_jvim12450-bib-0002","doi-asserted-by":"crossref","first-page":"S142","DOI":"10.1053\/ajkd.1998.v32.pm9820472","article-title":"Hyperlipidemia in patients with chronic renal disease","volume":"32","author":"Kasiske","year":"1998","journal-title":"Am J Kidney Dis"},{"key":"2026020304405945600_jvim12450-bib-0003","doi-asserted-by":"crossref","first-page":"S112","DOI":"10.1053\/ajkd.1998.v32.pm9820470","article-title":"Clinical epidemiology of cardiovascular disease in chronic renal disease","volume":"32","author":"Foley","year":"1998","journal-title":"Am J Kideny Dis"},{"key":"2026020304405945600_jvim12450-bib-0004","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000345176","article-title":"Reasons for the lack of salutary effects of cholesterol-lowering interventions in end-stage renal disease populations","volume":"35","author":"Vaziri","year":"2013","journal-title":"Blood Purif"},{"key":"2026020304405945600_jvim12450-bib-0005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1185\/03007995.2013.842165","article-title":"Safety and efficacy of statin treatment alone and in combination with fibrates in patients with dyslipidemia: A meta-analysis","volume":"30","author":"Choi","year":"2014","journal-title":"Curr Med Res Opin"},{"key":"2026020304405945600_jvim12450-bib-0006","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1161\/01.RES.35.5.722","article-title":"Canine lipoproteins and atherosclerosis. 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