{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T21:20:12Z","timestamp":1778793612260,"version":"3.51.4"},"reference-count":36,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Comparative Gastroenterology Society (CGS)\/Waltham Foundation"},{"name":"University of Tennessee fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acid suppressant drugs are a mainstay of treatment for cats with gastrointestinal erosion and ulceration. However, clinical studies have not been performed to compare the efficacy of commonly PO administered acid suppressants in cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>To compare the effect of PO administered famotidine, fractionated omeprazole tablet (fOT), and omeprazole reformulated paste (ORP) on intragastric pH in cats. We hypothesized that both omeprazole formulations would be superior to famotidine and placebo.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Six healthy adult DSH colony cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Utilizing a randomized, 4-way crossover design, cats received 0.88\u20131.26\u00a0mg\/kg PO q12h fOT, ORP, famotidine, and placebo (lactose capsules). Intragastric pH monitoring was used to continuously record intragastric pH for 96\u00a0hours beginning on day 4 of treatment. Plasma omeprazole concentrations at steady state (day 7) were determined by high performance liquid chromatography (HPLC) with ultraviolet detection. Mean percentage time that intragastric pH was \u22653 and \u22654 were compared among groups using ANOVA with a posthoc Tukey-Kramer test (\u03b1\u00a0=\u00a00.05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The mean percentage time\u00a0\u00b1\u00a0SD that intragastric pH was \u22653 was 68.4\u00a0\u00b1\u00a035.0% for fOT, 73.9\u00a0\u00b1\u00a023.2% for ORP, 42.8\u00a0\u00b1\u00a018.6% for famotidine, and 16.0\u00a0\u00b1\u00a014.2% for placebo. Mean\u00a0\u00b1\u00a0SD plasma omeprazole concentrations were similar in cats receiving fOT compared to those receiving ORP and in a range associated with acid suppression reported in other studies.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>These results suggest that both omeprazole formulations provide superior acid suppression in cats compared to famotidine or placebo. Fractionated enteric-coated OT is an effective acid suppressant despite disruption of the enteric coating.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12493","type":"journal-article","created":{"date-parts":[[2014,12,24]],"date-time":"2014-12-24T00:52:04Z","timestamp":1419382324000},"page":"104-112","source":"Crossref","is-referenced-by-count":47,"title":["Evaluation of the Effect of Orally Administered Acid Suppressants On Intragastric pH in Cats"],"prefix":"10.1093","volume":"29","author":[{"given":"S.","family":"Parkinson","sequence":"first","affiliation":[{"name":"University of Tennessee College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Knoxville, TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Tolbert","sequence":"additional","affiliation":[{"name":"University of Tennessee College of Veterinary Medicine Department of Small Animal Clinical Sciences, , Knoxville, 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