{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T15:46:50Z","timestamp":1784130410889,"version":"3.55.0"},"reference-count":34,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Novartis Animal Health Fellowship Research Program"},{"name":"Vector Borne Diseases Research Fund"},{"name":"North Carolina Veterinary Medical Foundation"},{"DOI":"10.13039\/100014851","name":"Bayer Animal Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014851","id-type":"DOI","asserted-by":"publisher"}]},{"name":"NIH Ruth L. Kirschstein National Research Service Award","award":["T32OD011130"],"award-info":[{"award-number":["T32OD011130"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Recently, a potential association was identified between Bartonella exposure and arthritides in mammalian species other than cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>We hypothesized that Bartonella exposure is associated with more severe degenerative joint disease (DJD) and a greater burden of DJD-associated pain in client-owned cats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Ninety-four client-owned cats (6\u00a0months to 20\u00a0years old), ranging from clinically unaffected to severely lame because of DJD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using physical examination and radiography, pain and radiographic scores were assigned to each part of the bony skeleton. Sera were tested for Bartonella henselae, B.\u00a0koehlerae, and B.\u00a0vinsonii subsp. berkhoffii (genotypes I, II, and III) antibodies using immunofluorescence antibody assays. Variables were categorized and logistic regression used to explore associations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Seropositivity to Bartonella was identified in 33 (35.1%) cats. After multivariate analysis controlling for age, total DJD score (OR, 0.51; 95% CI, 0.26\u20130.97; P\u00a0=\u00a0.042), appendicular pain score (OR, 0.33; 95% CI, 0.17\u20130.65; P\u00a0=\u00a0.0011), and total pain score (OR, 0.35; 95% CI, 0.17\u20130.72; P\u00a0=\u00a0.0045) were significantly inversely associated with Bartonella seroreactivity status, indicating that cats with higher DJD and pain scores were less likely to be Bartonella seropositive.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Based upon this preliminary study, Bartonella spp. seropositivity was associated with decreased severity of DJD and decreased DJD-associated pain in cats. Additional studies are needed to verify these findings, and if verified, to explore potential mechanisms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12495","type":"journal-article","created":{"date-parts":[[2014,10,18]],"date-time":"2014-10-18T08:07:06Z","timestamp":1413619626000},"page":"21-27","source":"Crossref","is-referenced-by-count":4,"title":["Relationship Between Degenerative Joint Disease, Pain, and\n                    <i>Bartonella<\/i>\n                    spp. Seroreactivity in Domesticated Cats"],"prefix":"10.1093","volume":"29","author":[{"given":"A.","family":"Tomas","sequence":"first","affiliation":[{"name":"Comparative Pain Research Laboratory , Department of Clinical Sciences, College of Veterinary Medicine, North Carolina State University, Raleigh, NC"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.L.","family":"Pultorak","sequence":"additional","affiliation":[{"name":"Intracellular Pathogens Research Laboratory , Department 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