{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:04:50Z","timestamp":1791266690627,"version":"4.1.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2015,1,1]],"date-time":"2015-01-01T00:00:00Z","timestamp":1420070400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Royal Canin SAS France"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cats with hypertrophic cardiomyopathy (HCM) are larger and have higher insulin-like growth factor-1 (IGF-1) concentrations than cats without HCM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>The aim of this study was to assess echocardiographic findings in a colony of adult cats to determine the relationship between early growth and left ventricular hypertrophy (LVH).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty-eight neutered adult cats (20 males, 8 females) from a colony \u22653\u00a0years of age for which growth curves were available.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case\u2013control study. Physical examination and echocardiography were performed, and body weight, body condition score (BCS), and head length and width were measured. Circulating glucose, insulin, N-terminal pro-B-type natriuretic peptide (NT-proBNP), and IGF-1 concentrations were measured and growth data were collected. Stepwise multivariate analyses were performed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mean age was 5.2\u00a0\u00b1\u00a01.1 years. Current BCSs ranged from 4 to 9 (median, 6) and mean body weight was 4.88\u00a0\u00b1\u00a01.29\u00a0kg. Variation in body weight was apparent by 6 (mean\u00a0=\u00a03.26\u00a0\u00b1\u00a00.80\u00a0kg) and 12\u00a0months of age (mean\u00a0=\u00a04.02\u00a0\u00b1\u00a01.02\u00a0kg). Cardiac abnormalities included a cardiac murmur (n\u00a0=\u00a07; 24%), gallop (n\u00a0=\u00a03; 10%), and arrhythmia (n\u00a0=\u00a01; 4%). Fourteen of 28 cats (50%) had echocardiographic evidence of LVH. Head width (P\u00a0=\u00a0.017), body weight (P\u00a0&amp;lt;\u00a0.001), NT-proBNP (P\u00a0=\u00a0.023), and IGF-1 (P\u00a0=\u00a0.013\u2013.022) were significantly associated with selected measures of LVH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Potential associations between body size, IGF-1, LVH, and HCM warrant future prospective studies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12503","type":"journal-article","created":{"date-parts":[[2014,11,20]],"date-time":"2014-11-20T07:09:15Z","timestamp":1416467355000},"page":"150-156","source":"Crossref","is-referenced-by-count":16,"title":["Relationship of Body Size to Metabolic Markers and Left Ventricular Hypertrophy in Cats"],"prefix":"10.1093","volume":"29","author":[{"given":"L.M.","family":"Freeman","sequence":"first","affiliation":[{"name":"Tufts Cummings School of 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