{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T06:25:56Z","timestamp":1791440756032,"version":"4.3.3"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":4051,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Human Resource Training Project for Regional Innovation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chronic mitral valvular insufficiency (CMVI) in dogs is very common and might cause clinical signs of congestion and poor tissue perfusion.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis<\/jats:title>\n                    <jats:p>Poor tissue perfusion from CMVI causes pancreatitis in dogs, as indicated by serum pancreatic lipase concentrations.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Sixty-two client-owned dogs consisting of 40 dogs with different stages of heart failure from CMVI and 22 age-matched healthy dogs, based on full cardiac exam and routine laboratory tests.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective, controlled, observational study. Serum canine pancreatic lipase immunoreactivity (cPLI) concentrations were determined by quantitative cPLI test in healthy and CMVI groups.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Serum cPLI concentrations were 54.0\u00a0\u03bcg\/L (IQR: 38.0\u201378.8\u00a0\u03bcg\/L) in control, 55.0\u00a0\u03bcg\/L (IQR: 38.3\u201388.8\u00a0\u03bcg\/L) in ISACHC I, 115.0\u00a0\u03bcg\/L (IQR: 45.0\u2013179.0\u00a0\u03bcg\/L) in ISACHC II and 223.0\u00a0\u03bcg\/L (IQR: 119.5\u2013817.5\u00a0\u03bcg\/L) in ISACHC III. Close correlation to serum cPLI concentration was found in the left atrial to aorta (LA\/Ao) ratio (r\u00a0=\u00a00.597; P\u00a0=\u00a0.000) and the severity of heart failure (r\u00a0=\u00a00.530; P\u00a0=\u00a0.000).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>This study found CMVI is associated with pancreatic injury in congestive heart failure caused by CMVI. Therefore, periodic monitoring on cPLI could be useful in monitoring dogs in heart failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12521","type":"journal-article","created":{"date-parts":[[2015,1,14]],"date-time":"2015-01-14T01:38:03Z","timestamp":1421199483000},"page":"180-183","source":"Crossref","is-referenced-by-count":24,"title":["Canine Pancreatic-Specific Lipase Concentrations in Dogs with Heart Failure and Chronic Mitral Valvular Insufficiency"],"prefix":"10.1093","volume":"29","author":[{"given":"D.","family":"Han","sequence":"first","affiliation":[{"name":"Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University , Chuncheon,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Choi","sequence":"additional","affiliation":[{"name":"Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University , Chuncheon,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hyun","sequence":"additional","affiliation":[{"name":"Section of Small Animal Internal Medicine, College of Veterinary Medicine, Kangwon National University , Chuncheon,","place":["South Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,1,1]]},"reference":[{"key":"2026020304425976300_jvim12521-bib-0001","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1111\/j.1939-1676.2009.0392.x","article-title":"Guidelines for the diagnosis and treatment of canine chronic valvular heart disease","volume":"23","author":"Atkins","year":"2009","journal-title":"J Vet Intern Med"},{"key":"2026020304425976300_jvim12521-bib-0002","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cvsm.2010.03.008","article-title":"Canine degenerative myxomatous mitral valve disease: Natural history, clinical presentation and therapy","volume":"40","author":"Borgarelli","year":"2010","journal-title":"Vet Clin North Am Small Anim Pract"},{"key":"2026020304425976300_jvim12521-bib-0003","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1172\/JCI11003","article-title":"Brain tissue responses to ischemia","volume":"106","author":"Lee","year":"2000","journal-title":"J Clin Invest"},{"key":"2026020304425976300_jvim12521-bib-0004","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/wsbm.133","article-title":"Ischemic kidney injury and mechanisms of tissue repair","volume":"3","author":"El Sabbahy","year":"2011","journal-title":"Wiley Interdiscip Rev Syst Biol Med"},{"key":"2026020304425976300_jvim12521-bib-0005","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/S0016-5085(96)70072-0","article-title":"Effects of ischemia on the human pancreas","volume":"111","author":"Gullo","year":"1996","journal-title":"Gastroenterology"},{"key":"2026020304425976300_jvim12521-bib-0006","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000018793","article-title":"Ischemia\/reperfusion-induced pancreatitis","volume":"17","author":"Sakorafas","year":"2000","journal-title":"Dig Surg"},{"key":"2026020304425976300_jvim12521-bib-0007","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/01.mpa.0000297712.13843.c3","article-title":"Ischemic acute pancreatitis: Clinical features, diagnosis","volume":"35","author":"Hackert","year":"2007","journal-title":"Therapy and Outcome. Pancreas"},{"key":"2026020304425976300_jvim12521-bib-0008","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1097\/00000658-197808000-00012","article-title":"Susceptibility of the pancreas to ischemic injury in shock","volume":"188","author":"Warshaw","year":"1978","journal-title":"Ann Surg"},{"key":"2026020304425976300_jvim12521-bib-0009","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1093\/eurheartj\/ehp507","article-title":"Cardio-renal syndromes: Report from the consensus conference of the acute dialysis quality initiative","volume":"31","author":"Ronco","year":"2010","journal-title":"Eur Heart J"},{"key":"2026020304425976300_jvim12521-bib-0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/eurheartj\/ehi020","article-title":"The severe cardiorenal syndrome: \u2018Guyton revisited\u2019","volume":"26","author":"Bongartz","year":"2005","journal-title":"Eur Heart J"},{"key":"2026020304425976300_jvim12521-bib-0011","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1111\/j.1939-1676.2007.tb03047.x","article-title":"Azotemia and glomerular filtration rate in dogs with chronic valvular disease","volume":"21","author":"Nicolle","year":"2007","journal-title":"J Vet Intern Med"},{"key":"2026020304425976300_jvim12521-bib-0012","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jacc.2008.07.051","article-title":"Cardiorenal syndrome","volume":"52","author":"Ronco","year":"2008","journal-title":"J Am Coll Cardiol"},{"key":"2026020304425976300_jvim12521-bib-0013","first-page":"175","article-title":"Development\u00a0and\u00a0analytic validation of an enzyme-linked immunosorbent\u00a0assay for the measurement of canine pancreatic lipase immunoreactivity in serum","volume":"67","author":"Steiner","year":"2003","journal-title":"Can J Vet Res"},{"key":"2026020304425976300_jvim12521-bib-0014","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.2460\/ajvr.2003.64.1237","article-title":"Development and validation of a radioimmunoassay for the measurement of canine pancreatic lipase immunoreactivity in serum of dogs","volume":"64","author":"Steiner","year":"2003","journal-title":"Am J Vet Res"},{"key":"2026020304425976300_jvim12521-bib-0015","first-page":"1999","volume-title":"Textbook of Canine and Feline Cardiology","author":"Fox"},{"key":"2026020304425976300_jvim12521-bib-0016","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jvc.2011.11.005","article-title":"Echocardiographic assessment of canine degenerative mitral valve disease","volume":"14","author":"Chetboul","year":"2012","journal-title":"J Vet Cardiol"},{"key":"2026020304425976300_jvim12521-bib-0017","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1007\/BF01296012","article-title":"Role of ischemia in acute pancreatitis. Hemorrhagic shock converts edematous pancreatitis to hemorrhagic pancreatitis in rats","volume":"37","author":"Kyogoku","year":"1992","journal-title":"Dig Dis Sci"},{"key":"2026020304425976300_jvim12521-bib-0018","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1136\/inp.f6018","article-title":"Dietary considerations for the cardiac patient","volume":"38","author":"Moneva-Jordan","year":"2012","journal-title":"In Practice"}],"container-title":["Journal of Veterinary Internal Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvim.12521","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjvim.12521","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/29\/1\/180\/66688448\/jvim12521.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/jvim\/article-pdf\/29\/1\/180\/66688448\/jvim12521.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T09:43:05Z","timestamp":1770111785000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/jvim\/article\/29\/1\/180\/8452648"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,1]]},"references-count":18,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2015,1,1]]}},"URL":"https:\/\/doi.org\/10.1111\/jvim.12521","relation":{},"ISSN":["1939-1676"],"issn-type":[{"value":"1939-1676","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2015,1]]},"published":{"date-parts":[[2015,1,1]]}}}