{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:56:25Z","timestamp":1791312985510,"version":"4.3.1"},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2015,3,1]],"date-time":"2015-03-01T00:00:00Z","timestamp":1425168000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"James R. Harkness fund"},{"name":"Wayne D. & Josephine H. Spangler Endowment Funds"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blastomycosis is a potentially fatal fungal disease that most commonly affects humans and dogs. The organism causes systemic inflammation and has a predilection for the lungs. The inflammation might lead to a hypercoagulable state with microemboli in the pulmonary circulation which could contribute to inadequate oxygen exchange in infected dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>Dogs with blastomycosis will be hypercoagulable compared with healthy case-matched controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Client-owned dogs with a diagnosis of blastomycosis (n\u00a0=\u00a023) and healthy case-matched controls (n\u00a0=\u00a023).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Prospective case-controlled study of client-owned dogs presented to a veterinary teaching hospital with clinical signs compatible with blastomycosis. Complete blood counts, fibrinogen, PT, aPTT, thromboelastometry (TE), thrombin antithrombin complexes (TAT), and thrombin generation were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Cases had a leukocytosis compared with controls [mean (SD) 16.6 (7.6)\u00a0\u00d7\u00a0103\/\u03bcL versus 8.2 (1.8)\u00a0\u00d7\u00a0103\/\u03bcL, P\u00a0&amp;lt;\u00a0.001], hyperfibrinogenemia [median 784\u00a0mg\/dL, range 329\u20131,443 versus median 178\u00a0mg\/dL, range 82\u2013257, P\u00a0&amp;lt;\u00a0.001], and increased TAT concentrations [mean (SD) 9.0 (5.7)\u00a0\u03bcg\/L versus 2.0 (2.8)\u00a0\u03bcg\/L, P\u00a0&amp;lt;\u00a0.001]. As compared to controls, cases were also hypercoagulable as evaluated by thromboelastometry and had increased in vitro thrombin generation on calibrated automated thrombography.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Hypercoagulability occurs in dogs with systemic blastomycosis. Additional studies are needed to explore a possible contribution of thrombogenicity to the clinical manifestations of systemic blastomycosis.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12538","type":"journal-article","created":{"date-parts":[[2015,3,28]],"date-time":"2015-03-28T23:33:58Z","timestamp":1427585638000},"page":"499-504","source":"Crossref","is-referenced-by-count":18,"title":["Hypercoagulability in Dogs with Blastomycosis"],"prefix":"10.1093","volume":"29","author":[{"given":"M.A.","family":"McMichael","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine, University of Illinois Department of Veterinary Clinical Sciences, , Urbana, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"O'Brien","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, University of Illinois Department of Veterinary Clinical Sciences, , Urbana, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.A.","family":"Smith","sequence":"additional","affiliation":[{"name":"College of Liberal Arts and Sciences, University of Illinois Department of Biochemistry, , Urbana, IL"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2015,3,1]]},"reference":[{"key":"2026020600222985200_jvim12538-bib-0001","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1053\/adpa.2001.21473","article-title":"Acute respiratory distress syndrome and blastomycosis: Presentation of nine cases and review of the literature","volume":"5","author":"Lemos","year":"2001","journal-title":"Ann Diagn Pathol"},{"key":"2026020600222985200_jvim12538-bib-0002","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1378\/chest.114.2.436","article-title":"Blastomycosis in northeast 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