{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:49:01Z","timestamp":1792018141932,"version":"4.4.0"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3992,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Advancing Canadian Agriculture and Agri-Food"},{"DOI":"10.13039\/100012190","name":"Alberta Beef Producers","doi-asserted-by":"publisher","award":["0007-038RDB"],"award-info":[{"award-number":["0007-038RDB"]}],"id":[{"id":"10.13039\/100012190","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Canadian Cattlemen's Association"},{"DOI":"10.13039\/501100005019","name":"Beef Cattle Research Council","doi-asserted-by":"publisher","award":["BCRC 6.41"],"award-info":[{"award-number":["BCRC 6.41"]}],"id":[{"id":"10.13039\/501100005019","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001003","name":"Boehringer Ingelheim","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001003","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Mannheimia haemolytica is an important etiological agent in bovine respiratory disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Explore risk factors for recovery of susceptible and resistant M.\u00a0haemolytica in feedlot cattle and explore associations with health outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Cattle (n\u00a0=\u00a05,498) from 4 feedlots sampled at arrival and later in feeding period.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Susceptibility of M.\u00a0haemolytica isolates tested for 21 antimicrobials. Records of antimicrobial use and health events analyzed using multivariable regression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>M.\u00a0haemolytica recovered from 29% of cattle (1,596\/5,498), 13.1% at arrival (95% CI, 12.3\u201314.1%), and 19.8% at second sampling (95% CI, 18.7\u201320.9%). Nearly half of study cattle received antimicrobial drugs (AMDs) parenterally, mostly as metaphylactic treatment at arrival. Individual parenteral AMD exposures were associated with decreased recovery of M.\u00a0haemolytica (OR, 0.2; 95% CI, 0.02\u20131.2), whereas exposure in penmates was associated with increased recovery (OR, 1.5; 95% CI, 1.05\u20132.2). Most isolates were pan-susceptible (87.8%; 95% CI, 87.0\u201389.4%). AMD exposures were not associated with resistance to any single drug. Multiply-resistant isolates were rare (5.9%; 95% CI, 5.1\u20136.9%), but AMD exposures in pen mates were associated with increased odds of recovering multiply-resistant M.\u00a0haemolytica (OR, 23.9; 95% CI, 8.4\u201368.3). Cattle positive for M.\u00a0haemolytica on arrival were more likely to become ill within 10\u00a0days (OR, 1.7; 95% CI, 1.1\u20132.4).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Resistance generally was rare in M.\u00a0haemolytica. Antimicrobial drug exposures in penmates increased the risk of isolating susceptible and multiply-resistant M.\u00a0haemolytica, a finding that could be explained by contagious spread.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12547","type":"journal-article","created":{"date-parts":[[2015,3,28]],"date-time":"2015-03-28T23:33:58Z","timestamp":1427585638000},"page":"705-713","source":"Crossref","is-referenced-by-count":73,"title":["<i>Mannheimia haemolytica<\/i>\n                    in Feedlot Cattle: Prevalence of Recovery and Associations with Antimicrobial Use, Resistance, and Health Outcomes"],"prefix":"10.1093","volume":"29","author":[{"given":"N.R.","family":"Noyes","sequence":"first","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Clinical Sciences, , Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.M.","family":"Benedict","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine and Biomedical Sciences, Colorado State University Department of Clinical Sciences, , Fort Collins, CO"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.P.","family":"Gow","sequence":"additional","affiliation":[{"name":"Laboratory for Foodborne Zoonoses, Public Health Agency of Canada, University of Saskatchewan , Saskatoon, SK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.W.","family":"Booker","sequence":"additional","affiliation":[{"name":"Feedlot Health Management Services Ltd. 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