{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:44:00Z","timestamp":1789695840815,"version":"4.0.1"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3992,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Pulmonary hypertension (PH) is common in dogs with myxomatous mitral valve disease (MMVD) but its effect on clinical outcome has not been investigated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/objectives<\/jats:title>\n                    <jats:p>The presence of PH worsens the outcome in dogs with MMVD. To compare survival times of dogs with MMVD and PH to those without PH.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Two hundred and twelve client-owned dogs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Case review study. Medical records of dogs diagnosed with ACVIM stage B2 and C MMVD between January 2010 and December 2011 were retrospectively reviewed. Long-term outcome was determined by telephone interview or from the medical record. End of the observation period was March 2013. PH was identified if tricuspid regurgitation peak velocity was &amp;gt;3\u00a0m\/s.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Two hundred and twelve were identified. Eighty-three dogs (39%) had PH. PH was more commonly identified in stage C compared to B2 (P\u00a0&amp;lt;\u00a0.0001). One hundred and five (49.5%) dogs died during the observation period. Median survival time for the entire study population was 567\u00a0days (95% CI 512\u2013743). Stage C (P\u00a0=\u00a0.003), the presence of PH (P\u00a0=\u00a0.009), left atrial to aortic root ratio (LA\/Ao) &amp;gt;1.7 (P\u00a0=\u00a0.0002), normalized left-ventricular end-diastolic diameter (LVEDn) &amp;gt;1.73 (P\u00a0=\u00a0.048), and tricuspid regurgitation pressure gradient (TRPG) &amp;gt;55\u00a0mmHg (P\u00a0=\u00a0.009) were associated with worse outcomes in the univariate analyses. The presence of TRPG &amp;gt;55\u00a0mmHg (HR 1.8 95% CI 1\u20132.9; P\u00a0=\u00a0.05) and LA\/Ao\u00a0&amp;gt;\u00a01.7 (HR 2 95% CI 1.2\u20133.4; P\u00a0=\u00a0.01) remained significant predictors of worse outcome in the multivariate analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>In dogs with MMVD, moderate to severe PH worsens outcome.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12564","type":"journal-article","created":{"date-parts":[[2015,3,28]],"date-time":"2015-03-28T23:33:58Z","timestamp":1427585638000},"page":"569-574","source":"Crossref","is-referenced-by-count":123,"title":["Prevalence and Prognostic Importance of Pulmonary Hypertension in Dogs with Myxomatous Mitral Valve Disease"],"prefix":"10.1093","volume":"29","author":[{"given":"M.","family":"Borgarelli","sequence":"first","affiliation":[{"name":"Virginia-Maryland College of Veterinary Medicine, Virginia Tech , Blacksburg, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Abbott","sequence":"additional","affiliation":[{"name":"Virginia-Maryland College of Veterinary Medicine, Virginia Tech , Blacksburg, VA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Braz-Ruivo","sequence":"additional","affiliation":[{"name":"Dogs and Cats Veterinary Referral & ER , Bowie, MD"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Chiavegato","sequence":"additional","affiliation":[{"name":"Clinica Veterinaria Arcella , Padova,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Crosara","sequence":"additional","affiliation":[{"name":"University of Parma Department of Veterinary 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