{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T05:25:02Z","timestamp":1784870702464,"version":"3.55.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3931,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009449","name":"Petplan Charitable Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009449","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>To date, epidemiological studies on degenerative mitral valve disease (DMVD) in dogs have largely reported referral caseloads or been limited to predisposed breeds. Analysis of primary-care data to identify factors associated with DMVD would help clinicians identify high-risk individuals and improve understanding.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To estimate the prevalence of and identify risk factors for DMVD in dogs attending primary-care veterinary practices in England.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Cases were identified within the electronic patient records of 111,967 dogs attending 93 practices. Four hundred and 5 dogs were diagnosed with DMVD (diagnosed cases) and a further 3,557 dogs had a heart murmur (HM) consistent with DMVD (possible cases).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective cross-sectional study design. Prevalence was adjusted for the sampling approach. Mixed effects logistic regression models identified factors associated with DMVD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Prevalence estimates of diagnosed DMVD and HMs consistent with DMVD (both diagnosed and possible cases) were 0.36% (95% confidence interval [CI]: 0.29\u20130.45) and 3.54% (95% CI: 3.26\u20133.84) respectively. In the multivariable analysis, males had higher odds of diagnosed DMVD than did females (odds ratio [OR] 1.40, 95% CI: 1.12\u20131.74). Insured dogs had increased odds of DMVD compared with noninsured dogs (OR 3.56, 95% CI: 2.79\u20134.55) and dogs \u226520\u00a0kg had approximately half the odds of DMVD diagnosis compared with dogs &amp;lt;20\u00a0kg (OR 0.51, 95% CI: 0.36\u20130.74). Strong associations between a DMVD diagnosis and individual breeds and age were identified.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>Degenerative mitral valve disease was a common disorder in practice-attending dogs. Knowledge of identified risk factors for DMVD could improve clinical diagnosis and direct future research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.12591","type":"journal-article","created":{"date-parts":[[2015,4,9]],"date-time":"2015-04-09T19:02:50Z","timestamp":1428606170000},"page":"847-854","source":"Crossref","is-referenced-by-count":76,"title":["Prevalence of and Risk Factors for Degenerative Mitral Valve Disease in Dogs Attending Primary-care Veterinary Practices in England"],"prefix":"10.1093","volume":"29","author":[{"given":"M.J.","family":"Mattin","sequence":"first","affiliation":[{"name":"Royal Veterinary College, University of London , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boswood","sequence":"additional","affiliation":[{"name":"Royal Veterinary College, University of London , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.B.","family":"Church","sequence":"additional","affiliation":[{"name":"Royal Veterinary College, University of London , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6082-1343","authenticated-orcid":false,"given":"J.","family":"L\u00f3pez-Alvarez","sequence":"additional","affiliation":[{"name":"Royal Veterinary College, University of London , London,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.D.","family":"McGreevy","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Science, University of Sydney , Sydney, NSW,","place":["Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.G.","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Royal Veterinary College, University of London , 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