{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T09:57:59Z","timestamp":1784627879209,"version":"3.55.0"},"reference-count":38,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3686,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Swedish Veterinary Care Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cobalamin deficiency is commonly associated with chronic enteropathies (CE) in dogs and current treatment protocols recommend parenteral supplementation. In humans, several studies have reported equal efficacy of oral and parenteral cobalamin administration of cobalamin.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To retrospectively evaluate whether oral cobalamin supplementation can restore normocobalaminemia in dogs with CE and hypocobalaminemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Fifty-one client-owned dogs with various signs of CE and hypocobalaminemia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Material and Methods<\/jats:title>\n                    <jats:p>Retrospective study based on a computerized database search for dogs treated at Evidensia Specialist Animal Hospital, Helsingborg, Sweden during January 2012\u2013March 2014. Inclusion criteria were dogs with signs of CE, an initial serum cobalamin \u2264270 ng\/L (reference interval: 234\u2013811 ng\/L) and oral treatment with cobalamin tablets. Serum cobalamin for follow-up was analyzed 20\u2013202 days after continuous oral cobalamin supplementation started.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All dogs became normocobalaminemic with oral cobalamin supplementation. The mean increase in serum cobalamin concentration after treatment was 794 \u00b1 462 ng\/L. Serum cobalamin concentrations were significantly higher after supplementation (mean 1017 \u00b1 460 ng\/L; P &amp;lt; .0001) than at baseline (mean 223 \u00b1 33 ng\/L).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Clinical Importance<\/jats:title>\n                    <jats:p>Our results suggest that oral cobalamin supplementation is effective in normalizing serum cobalamin concentrations in dogs with CE. Prospective studies comparing cellular cobalamin status in dogs being treated with parenteral versus oral cobalamin supplementation are warranted before oral supplementation can be recommended for routine supplementation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.13797","type":"journal-article","created":{"date-parts":[[2015,12,10]],"date-time":"2015-12-10T03:26:39Z","timestamp":1449717999000},"page":"101-107","source":"Crossref","is-referenced-by-count":51,"title":["Oral Cobalamin Supplementation in Dogs with Chronic Enteropathies and Hypocobalaminemia"],"prefix":"10.1093","volume":"30","author":[{"given":"L.","family":"Toresson","sequence":"first","affiliation":[{"name":"Faculty of Veterinary Medicine, Helsinki University Department of Equine and Small Animal Medicine, , Helsinki,","place":["Finland"]},{"name":"Evidensia Specialist Animal Hospital , 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