{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T22:39:16Z","timestamp":1779921556053,"version":"3.53.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":3626,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Post-graduate Research Fund"},{"name":"McGeorge Research Fund"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2016,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Dog breeds with the ABCB1-1\u0394 mutation have substantially truncated nonfunctional P-glycoprotein. Dogs homozygous for this mutation (mut\/mut) are susceptible to the toxic adverse effects of ivermectin, loperamide, and vincristine. Anecdotal reports suggested ABCB1 mut\/mut dogs showed increased depth and duration of acepromazine sedation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Hypothesis\/Objectives<\/jats:title>\n                    <jats:p>That ABCB1 mut\/mut dogs have increased depth and duration of sedation after acepromazine IV compared to normal dogs (nor\/nor).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Animals<\/jats:title>\n                    <jats:p>Twenty-nine rough-coated collies were divided into 3 groups of dogs based on their ABCB1 genotype: 10 mut\/mut, 10 mut\/nor, and 9 nor\/nor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Dogs were given 0.04 mg\/kg of acepromazine IV. Level of sedation, heart rate, respiratory rate, and blood pressure were recorded for 6 hours after acepromazine administration. Area under the curves (AUCs) of the normalized sedation score results were calculated and compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The median sedation scores for ABCB1 mut\/mut dogs were higher than nor\/nor dogs at all time points and were higher in mut\/nor dogs for the first 2 hours. These differences were not found to be significant for any individual time point (P &amp;gt; .05). The median sedation score AUC for mut\/mut dogs was significantly higher than nor\/nor dogs (P = .028), but the AUC for mut\/nor dogs was not (P = .45). There were no significant differences between groups for heart rate, respiratory rate, and blood pressure (P &amp;gt; .05).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Clinical Importance<\/jats:title>\n                    <jats:p>In ABCB1 mut\/mut dogs acepromazine dose rates should be reduced and careful monitoring performed during sedation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jvim.13827","type":"journal-article","created":{"date-parts":[[2016,1,29]],"date-time":"2016-01-29T01:36:45Z","timestamp":1454031405000},"page":"636-641","source":"Crossref","is-referenced-by-count":25,"title":["The Effect of the Canine\n                    <i>ABCB1<\/i>\n                    -1\u0394 Mutation on Sedation after Intravenous Administration of Acepromazine"],"prefix":"10.1093","volume":"30","author":[{"given":"D.","family":"Deshpande","sequence":"first","affiliation":[{"name":"Institute of Veterinary, Animal and Biomedical Sciences, Massey University , Palmerston North,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1549-8828","authenticated-orcid":false,"given":"K.E.","family":"Hill","sequence":"additional","affiliation":[{"name":"Institute of Veterinary, Animal and Biomedical Sciences, Massey University , Palmerston North,","place":["New Zealand"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.L.","family":"Mealey","sequence":"additional","affiliation":[{"name":"College of Veterinary Medicine, Washington State University Department of Veterinary Clinical Sciences, , Pullman, WA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.P.","family":"Chambers","sequence":"additional","affiliation":[{"name":"Institute of Veterinary, Animal and Biomedical Sciences, Massey University , Palmerston North,","place":["New 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